NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock

We herein report the result of a large-scale, next generation sequencing (NGS)-based screen for embryonic lethal (EL) mutations in Belgian beef and New Zealand dairy cattle. We estimated by simulation that cattle might carry, on average, ∼0.5 recessive EL mutations. We mined exome sequence data from...

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Detalles Bibliográficos
Autores principales: Charlier, Carole, Li, Wanbo, Harland, Chad, Littlejohn, Mathew, Coppieters, Wouter, Creagh, Frances, Davis, Steve, Druet, Tom, Faux, Pierre, Guillaume, François, Karim, Latifa, Keehan, Mike, Kadri, Naveen Kumar, Tamma, Nico, Spelman, Richard, Georges, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052051/
https://www.ncbi.nlm.nih.gov/pubmed/27646536
http://dx.doi.org/10.1101/gr.207076.116

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