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IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis
Myocardial injuries in viral myocarditis (VMC) are caused by viral infection and related autoimmune disorders. Recent studies suggest that IL-9 mediated both antimicrobial immune and autoimmune responses in addition to allergic diseases. However, the role of IL-9 in viral infection and VMC remains c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052262/ https://www.ncbi.nlm.nih.gov/pubmed/27766098 http://dx.doi.org/10.3389/fimmu.2016.00409 |
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author | Yu, Miao Long, Qi Li, Huan-Huan Liang, Wei Liao, Yu-Hua Yuan, Jing Cheng, Xiang |
author_facet | Yu, Miao Long, Qi Li, Huan-Huan Liang, Wei Liao, Yu-Hua Yuan, Jing Cheng, Xiang |
author_sort | Yu, Miao |
collection | PubMed |
description | Myocardial injuries in viral myocarditis (VMC) are caused by viral infection and related autoimmune disorders. Recent studies suggest that IL-9 mediated both antimicrobial immune and autoimmune responses in addition to allergic diseases. However, the role of IL-9 in viral infection and VMC remains controversial and uncertain. In this study, we infected Balb/c mice with Coxsackievirus B3 (CVB3), and found that IL-9 was enriched in the blood and hearts of VMC mice on days 5 and 7 after virus infection. Most of IL-9 was secreted by CD8(+) T cells on day 5 and CD4(+) T cells on day 7 in the myocardium. Further, IL-9 knockout exacerbated cardiac damage following CVB3 infection, along with a sharp increase in viral replication and IL-17a expression, as well as a decrease in TGF-β. In contrast, the repletion of IL-9 in Balb/c mice with CVB infection induced the opposite effect. Studies in vitro further revealed that IL-9 directly inhibited viral replication in cardiomyocytes by reducing coxsackie and adenovirus receptor expression, which might be associated with upregulation of TGF-β autocrine effect in these cells. However, IL-9 had no direct effect on apoptosis in cardiomyocytes. Our data indicated that IL-9 played a protective role in disease progression by inhibiting CVB3 replication in the early stages of VMC. |
format | Online Article Text |
id | pubmed-5052262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50522622016-10-20 IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis Yu, Miao Long, Qi Li, Huan-Huan Liang, Wei Liao, Yu-Hua Yuan, Jing Cheng, Xiang Front Immunol Immunology Myocardial injuries in viral myocarditis (VMC) are caused by viral infection and related autoimmune disorders. Recent studies suggest that IL-9 mediated both antimicrobial immune and autoimmune responses in addition to allergic diseases. However, the role of IL-9 in viral infection and VMC remains controversial and uncertain. In this study, we infected Balb/c mice with Coxsackievirus B3 (CVB3), and found that IL-9 was enriched in the blood and hearts of VMC mice on days 5 and 7 after virus infection. Most of IL-9 was secreted by CD8(+) T cells on day 5 and CD4(+) T cells on day 7 in the myocardium. Further, IL-9 knockout exacerbated cardiac damage following CVB3 infection, along with a sharp increase in viral replication and IL-17a expression, as well as a decrease in TGF-β. In contrast, the repletion of IL-9 in Balb/c mice with CVB infection induced the opposite effect. Studies in vitro further revealed that IL-9 directly inhibited viral replication in cardiomyocytes by reducing coxsackie and adenovirus receptor expression, which might be associated with upregulation of TGF-β autocrine effect in these cells. However, IL-9 had no direct effect on apoptosis in cardiomyocytes. Our data indicated that IL-9 played a protective role in disease progression by inhibiting CVB3 replication in the early stages of VMC. Frontiers Media S.A. 2016-10-06 /pmc/articles/PMC5052262/ /pubmed/27766098 http://dx.doi.org/10.3389/fimmu.2016.00409 Text en Copyright © 2016 Yu, Long, Li, Liang, Liao, Yuan and Cheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yu, Miao Long, Qi Li, Huan-Huan Liang, Wei Liao, Yu-Hua Yuan, Jing Cheng, Xiang IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis |
title | IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis |
title_full | IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis |
title_fullStr | IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis |
title_full_unstemmed | IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis |
title_short | IL-9 Inhibits Viral Replication in Coxsackievirus B3-Induced Myocarditis |
title_sort | il-9 inhibits viral replication in coxsackievirus b3-induced myocarditis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052262/ https://www.ncbi.nlm.nih.gov/pubmed/27766098 http://dx.doi.org/10.3389/fimmu.2016.00409 |
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