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MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience
PURPOSE: The purpose of this study was to compare three different biopsy devices on false-negative and underestimation rates in MR-guided, vacuum-assisted breast biopsy (VABB) of MRI-only lesions. METHODS: This retrospective, single-center study was IRB-approved. Informed consent was waived. 467 con...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052307/ https://www.ncbi.nlm.nih.gov/pubmed/26984430 http://dx.doi.org/10.1007/s00330-016-4267-9 |
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author | Spick, Claudio Schernthaner, Melanie Pinker, Katja Kapetas, Panagiotis Bernathova, Maria Polanec, Stephan H. Bickel, Hubert Wengert, Georg J. Rudas, Margaretha Helbich, Thomas H. Baltzer, Pascal A. |
author_facet | Spick, Claudio Schernthaner, Melanie Pinker, Katja Kapetas, Panagiotis Bernathova, Maria Polanec, Stephan H. Bickel, Hubert Wengert, Georg J. Rudas, Margaretha Helbich, Thomas H. Baltzer, Pascal A. |
author_sort | Spick, Claudio |
collection | PubMed |
description | PURPOSE: The purpose of this study was to compare three different biopsy devices on false-negative and underestimation rates in MR-guided, vacuum-assisted breast biopsy (VABB) of MRI-only lesions. METHODS: This retrospective, single-center study was IRB-approved. Informed consent was waived. 467 consecutive patients underwent 487 MR-guided VABB using three different 8-10-gauge-VABB devices (Atec-9-gauge,A; Mammotome-8-gauge,M; Vacora-10-gauge,V). VABB data (lesion-type, size, biopsy device, histopathology) were compared to final diagnosis (surgery, n = 210 and follow-up, n = 277). Chi-square, and Kruskal–Wallis tests were applied. P values < 0.05 were considered significant. RESULTS: Final diagnosis was malignant in 104 (21.4 %), high risk in 64 (13.1 %) and benign in 319 (65.5 %) cases. Eleven of 328 (3.4 %) benign-rated lesions were false-negative (1/95, 1.1 %, A; 2/73, 2.7 %, M; 8/160 5.0 % V; P = 0.095). Eleven high-risk (11/77, 14.3 %) lesions proved to be malignant (3/26, 11.5 % A; 4/12, 33.3 % M; 4/39, 10.3 % V; P = 0.228). Five of 34 (14.7 %) DCIS were upgraded to invasive cancer (2/15, 13.3 %, A; 1/6, 16.6 % M; 2/13, 15.3 %, V; P = 0.977). Lesion size (P = 0.05) and type (mass vs. non-mass, P = 0.107) did not differ significantly. CONCLUSION: MR-guided VABB is an accurate method for diagnosis of MRI-only lesions. No significant differences on false-negative and underestimation rates were observed between three different biopsy devices. KEY POINTS: • MR-guided VABB is an accurate procedure for the diagnosis of MRI-only lesions. • Similar false-negative and underestimation rates allow all three different MR-guided VABB devices for clinical application. • High-risk lesions should undergo surgery due to a substantial underestimation rate. • Agreement between MR-guided VABB and final diagnosis (benign/malignant) was 95.5% (465/487). |
format | Online Article Text |
id | pubmed-5052307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-50523072016-10-20 MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience Spick, Claudio Schernthaner, Melanie Pinker, Katja Kapetas, Panagiotis Bernathova, Maria Polanec, Stephan H. Bickel, Hubert Wengert, Georg J. Rudas, Margaretha Helbich, Thomas H. Baltzer, Pascal A. Eur Radiol Breast PURPOSE: The purpose of this study was to compare three different biopsy devices on false-negative and underestimation rates in MR-guided, vacuum-assisted breast biopsy (VABB) of MRI-only lesions. METHODS: This retrospective, single-center study was IRB-approved. Informed consent was waived. 467 consecutive patients underwent 487 MR-guided VABB using three different 8-10-gauge-VABB devices (Atec-9-gauge,A; Mammotome-8-gauge,M; Vacora-10-gauge,V). VABB data (lesion-type, size, biopsy device, histopathology) were compared to final diagnosis (surgery, n = 210 and follow-up, n = 277). Chi-square, and Kruskal–Wallis tests were applied. P values < 0.05 were considered significant. RESULTS: Final diagnosis was malignant in 104 (21.4 %), high risk in 64 (13.1 %) and benign in 319 (65.5 %) cases. Eleven of 328 (3.4 %) benign-rated lesions were false-negative (1/95, 1.1 %, A; 2/73, 2.7 %, M; 8/160 5.0 % V; P = 0.095). Eleven high-risk (11/77, 14.3 %) lesions proved to be malignant (3/26, 11.5 % A; 4/12, 33.3 % M; 4/39, 10.3 % V; P = 0.228). Five of 34 (14.7 %) DCIS were upgraded to invasive cancer (2/15, 13.3 %, A; 1/6, 16.6 % M; 2/13, 15.3 %, V; P = 0.977). Lesion size (P = 0.05) and type (mass vs. non-mass, P = 0.107) did not differ significantly. CONCLUSION: MR-guided VABB is an accurate method for diagnosis of MRI-only lesions. No significant differences on false-negative and underestimation rates were observed between three different biopsy devices. KEY POINTS: • MR-guided VABB is an accurate procedure for the diagnosis of MRI-only lesions. • Similar false-negative and underestimation rates allow all three different MR-guided VABB devices for clinical application. • High-risk lesions should undergo surgery due to a substantial underestimation rate. • Agreement between MR-guided VABB and final diagnosis (benign/malignant) was 95.5% (465/487). Springer Berlin Heidelberg 2016-03-16 2016 /pmc/articles/PMC5052307/ /pubmed/26984430 http://dx.doi.org/10.1007/s00330-016-4267-9 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Breast Spick, Claudio Schernthaner, Melanie Pinker, Katja Kapetas, Panagiotis Bernathova, Maria Polanec, Stephan H. Bickel, Hubert Wengert, Georg J. Rudas, Margaretha Helbich, Thomas H. Baltzer, Pascal A. MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience |
title | MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience |
title_full | MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience |
title_fullStr | MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience |
title_full_unstemmed | MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience |
title_short | MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience |
title_sort | mr-guided vacuum-assisted breast biopsy of mri-only lesions: a single center experience |
topic | Breast |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052307/ https://www.ncbi.nlm.nih.gov/pubmed/26984430 http://dx.doi.org/10.1007/s00330-016-4267-9 |
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