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Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review
Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052333/ https://www.ncbi.nlm.nih.gov/pubmed/27544394 http://dx.doi.org/10.1016/j.bjm.2016.06.006 |
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author | Ribas e Ribas, Aícha Daniela Spolti, Pierri Del Ponte, Emerson Medeiros Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello |
author_facet | Ribas e Ribas, Aícha Daniela Spolti, Pierri Del Ponte, Emerson Medeiros Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello |
author_sort | Ribas e Ribas, Aícha Daniela |
collection | PubMed |
description | Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments. |
format | Online Article Text |
id | pubmed-5052333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50523332016-10-12 Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review Ribas e Ribas, Aícha Daniela Spolti, Pierri Del Ponte, Emerson Medeiros Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello Braz J Microbiol Review Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments. Elsevier 2016-07-07 /pmc/articles/PMC5052333/ /pubmed/27544394 http://dx.doi.org/10.1016/j.bjm.2016.06.006 Text en © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Ribas e Ribas, Aícha Daniela Spolti, Pierri Del Ponte, Emerson Medeiros Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title | Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_full | Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_fullStr | Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_full_unstemmed | Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_short | Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_sort | is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? a mini review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052333/ https://www.ncbi.nlm.nih.gov/pubmed/27544394 http://dx.doi.org/10.1016/j.bjm.2016.06.006 |
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