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Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus

CONTEXT: The mechanism of action of metformin remains unclear. Given the regulation of the cortisol-regenerating enzyme 11βhydroxysteroid dehydrogenase 1 (11βHSD1) by insulin and the limited efficacy of selective 11βHSD1 inhibitors to lower blood glucose when co-prescribed with metformin, we hypothe...

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Detalles Bibliográficos
Autores principales:	Anderson, Anna J., Andrew, Ruth, Homer, Natalie Z., Jones, Gregory C., Smith, Kenneth, Livingstone, Dawn E., Walker, Brian R., Stimson, Roland H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052341/ https://www.ncbi.nlm.nih.gov/pubmed/27459533 http://dx.doi.org/10.1210/jc.2016-2069

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