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Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes
Contact heat evoked potentials (CHEPs) represent a neurophysiological approach to assess conduction in the spinothalamic tract. The aim of this study was to establish normative values of CHEPs acquired from cervical dermatomes (C4, C6, C8) and examine the potential confounds of age, sex, and height....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052572/ https://www.ncbi.nlm.nih.gov/pubmed/27708413 http://dx.doi.org/10.1038/srep34660 |
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author | Jutzeler, Catherine R. Rosner, Jan Rinert, Janosch Kramer, John L. K. Curt, Armin |
author_facet | Jutzeler, Catherine R. Rosner, Jan Rinert, Janosch Kramer, John L. K. Curt, Armin |
author_sort | Jutzeler, Catherine R. |
collection | PubMed |
description | Contact heat evoked potentials (CHEPs) represent a neurophysiological approach to assess conduction in the spinothalamic tract. The aim of this study was to establish normative values of CHEPs acquired from cervical dermatomes (C4, C6, C8) and examine the potential confounds of age, sex, and height. 101 (49 male) healthy subjects of three different age groups (18–40, 41–60, and 61–80 years) were recruited. Normal (NB, 35–52 °C) followed by increased (IB, 42–52 °C) baseline stimulation protocols were employed to record CHEPs. Multi-variate linear models were used to investigate the effect of age, sex, and height on the CHEPs parameters (i.e., N2 latency, N2P2 amplitude, rating of perceived intensity). Compared to NB, IB stimulation reduced latency jitter within subjects, yielding larger N2P2 amplitudes, and decreased inter-subject N2 latency variability. Age was associated with reduced N2P2 amplitude and prolonged N2 latency. After controlling for height, male subjects had significantly longer N2 latencies than females during IB stimulation. The study provides normative CHEPs data in a large cohort of healthy subjects from segmentally examined cervical dermatomes. Age and sex were identified as important factors contributing to N2 latency and N2P2 amplitude. The normative data will improve the diagnosis of spinal cord pathologies. |
format | Online Article Text |
id | pubmed-5052572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50525722016-10-19 Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes Jutzeler, Catherine R. Rosner, Jan Rinert, Janosch Kramer, John L. K. Curt, Armin Sci Rep Article Contact heat evoked potentials (CHEPs) represent a neurophysiological approach to assess conduction in the spinothalamic tract. The aim of this study was to establish normative values of CHEPs acquired from cervical dermatomes (C4, C6, C8) and examine the potential confounds of age, sex, and height. 101 (49 male) healthy subjects of three different age groups (18–40, 41–60, and 61–80 years) were recruited. Normal (NB, 35–52 °C) followed by increased (IB, 42–52 °C) baseline stimulation protocols were employed to record CHEPs. Multi-variate linear models were used to investigate the effect of age, sex, and height on the CHEPs parameters (i.e., N2 latency, N2P2 amplitude, rating of perceived intensity). Compared to NB, IB stimulation reduced latency jitter within subjects, yielding larger N2P2 amplitudes, and decreased inter-subject N2 latency variability. Age was associated with reduced N2P2 amplitude and prolonged N2 latency. After controlling for height, male subjects had significantly longer N2 latencies than females during IB stimulation. The study provides normative CHEPs data in a large cohort of healthy subjects from segmentally examined cervical dermatomes. Age and sex were identified as important factors contributing to N2 latency and N2P2 amplitude. The normative data will improve the diagnosis of spinal cord pathologies. Nature Publishing Group 2016-10-06 /pmc/articles/PMC5052572/ /pubmed/27708413 http://dx.doi.org/10.1038/srep34660 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Jutzeler, Catherine R. Rosner, Jan Rinert, Janosch Kramer, John L. K. Curt, Armin Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
title | Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
title_full | Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
title_fullStr | Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
title_full_unstemmed | Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
title_short | Normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
title_sort | normative data for the segmental acquisition of contact heat evoked potentials in cervical dermatomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052572/ https://www.ncbi.nlm.nih.gov/pubmed/27708413 http://dx.doi.org/10.1038/srep34660 |
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