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Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5′-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synt...

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Detalles Bibliográficos
Autores principales:	Corvino, Angela, Severino, Beatrice, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Bucci, Mariarosaria, Cirino, Giuseppe, Kelly, Geoff, Servillo, Luigi, Popowicz, Grzegorz, Pastore, Annalisa, Caliendo, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052628/ https://www.ncbi.nlm.nih.gov/pubmed/27708394 http://dx.doi.org/10.1038/srep34398

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