Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib–IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb–IX was identified. He...

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Detalles Bibliográficos
Autores principales: Deng, Wei, Xu, Yan, Chen, Wenchun, Paul, David S., Syed, Anum K., Dragovich, Matthew A., Liang, Xin, Zakas, Philip, Berndt, Michael C., Di Paola, Jorge, Ware, Jerry, Lanza, Francois, Doering, Christopher B., Bergmeier, Wolfgang, Zhang, X. Frank, Li, Renhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052631/
https://www.ncbi.nlm.nih.gov/pubmed/27670775
http://dx.doi.org/10.1038/ncomms12863

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