Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1

Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development. Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for thymocyte positive selection. In T cell-specific PKD-deficient (PKD2/PKD3 double-deficient) mice, the genera...

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Detalles Bibliográficos
Autores principales: Ishikawa, Eri, Kosako, Hidetaka, Yasuda, Tomoharu, Ohmuraya, Masaki, Araki, Kimi, Kurosaki, Tomohiro, Saito, Takashi, Yamasaki, Sho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052653/
https://www.ncbi.nlm.nih.gov/pubmed/27670070
http://dx.doi.org/10.1038/ncomms12756

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