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The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression
Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which comprise <1% of the genome. Here we levera...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052669/ https://www.ncbi.nlm.nih.gov/pubmed/27666543 http://dx.doi.org/10.1038/ncomms12791 |
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| author | Niknafs, Yashar S. Han, Sumin Ma, Teng Speers, Corey Zhang, Chao Wilder-Romans, Kari Iyer, Matthew K. Pitchiaya, Sethuramasundaram Malik, Rohit Hosono, Yasuyuki Prensner, John R. Poliakov, Anton Singhal, Udit Xiao, Lanbo Kregel, Steven Siebenaler, Ronald F. Zhao, Shuang G. Uhl, Michael Gawronski, Alexander Hayes, Daniel F. Pierce, Lori J. Cao, Xuhong Collins, Colin Backofen, Rolf Sahinalp, Cenk S. Rae, James M. Chinnaiyan, Arul M. Feng, Felix Y. |
| author_facet | Niknafs, Yashar S. Han, Sumin Ma, Teng Speers, Corey Zhang, Chao Wilder-Romans, Kari Iyer, Matthew K. Pitchiaya, Sethuramasundaram Malik, Rohit Hosono, Yasuyuki Prensner, John R. Poliakov, Anton Singhal, Udit Xiao, Lanbo Kregel, Steven Siebenaler, Ronald F. Zhao, Shuang G. Uhl, Michael Gawronski, Alexander Hayes, Daniel F. Pierce, Lori J. Cao, Xuhong Collins, Colin Backofen, Rolf Sahinalp, Cenk S. Rae, James M. Chinnaiyan, Arul M. Feng, Felix Y. |
| author_sort | Niknafs, Yashar S. |
| collection | PubMed |
| description | Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which comprise <1% of the genome. Here we leverage a compendium of 58,648 long noncoding RNAs (lncRNAs) to subtype 947 breast cancer samples. We show that lncRNA-based profiling categorizes breast tumours by their known molecular subtypes in breast cancer. We identify a cohort of breast cancer-associated and oestrogen-regulated lncRNAs, and investigate the role of the top prioritized oestrogen receptor (ER)-regulated lncRNA, DSCAM-AS1. We demonstrate that DSCAM-AS1 mediates tumour progression and tamoxifen resistance and identify hnRNPL as an interacting protein involved in the mechanism of DSCAM-AS1 action. By highlighting the role of DSCAM-AS1 in breast cancer biology and treatment resistance, this study provides insight into the potential clinical implications of lncRNAs in breast cancer. |
| format | Online Article Text |
| id | pubmed-5052669 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50526692016-10-21 The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression Niknafs, Yashar S. Han, Sumin Ma, Teng Speers, Corey Zhang, Chao Wilder-Romans, Kari Iyer, Matthew K. Pitchiaya, Sethuramasundaram Malik, Rohit Hosono, Yasuyuki Prensner, John R. Poliakov, Anton Singhal, Udit Xiao, Lanbo Kregel, Steven Siebenaler, Ronald F. Zhao, Shuang G. Uhl, Michael Gawronski, Alexander Hayes, Daniel F. Pierce, Lori J. Cao, Xuhong Collins, Colin Backofen, Rolf Sahinalp, Cenk S. Rae, James M. Chinnaiyan, Arul M. Feng, Felix Y. Nat Commun Article Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which comprise <1% of the genome. Here we leverage a compendium of 58,648 long noncoding RNAs (lncRNAs) to subtype 947 breast cancer samples. We show that lncRNA-based profiling categorizes breast tumours by their known molecular subtypes in breast cancer. We identify a cohort of breast cancer-associated and oestrogen-regulated lncRNAs, and investigate the role of the top prioritized oestrogen receptor (ER)-regulated lncRNA, DSCAM-AS1. We demonstrate that DSCAM-AS1 mediates tumour progression and tamoxifen resistance and identify hnRNPL as an interacting protein involved in the mechanism of DSCAM-AS1 action. By highlighting the role of DSCAM-AS1 in breast cancer biology and treatment resistance, this study provides insight into the potential clinical implications of lncRNAs in breast cancer. Nature Publishing Group 2016-09-26 /pmc/articles/PMC5052669/ /pubmed/27666543 http://dx.doi.org/10.1038/ncomms12791 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Niknafs, Yashar S. Han, Sumin Ma, Teng Speers, Corey Zhang, Chao Wilder-Romans, Kari Iyer, Matthew K. Pitchiaya, Sethuramasundaram Malik, Rohit Hosono, Yasuyuki Prensner, John R. Poliakov, Anton Singhal, Udit Xiao, Lanbo Kregel, Steven Siebenaler, Ronald F. Zhao, Shuang G. Uhl, Michael Gawronski, Alexander Hayes, Daniel F. Pierce, Lori J. Cao, Xuhong Collins, Colin Backofen, Rolf Sahinalp, Cenk S. Rae, James M. Chinnaiyan, Arul M. Feng, Felix Y. The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression |
| title | The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression |
| title_full | The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression |
| title_fullStr | The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression |
| title_full_unstemmed | The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression |
| title_short | The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression |
| title_sort | lncrna landscape of breast cancer reveals a role for dscam-as1 in breast cancer progression |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052669/ https://www.ncbi.nlm.nih.gov/pubmed/27666543 http://dx.doi.org/10.1038/ncomms12791 |
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