Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (...

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Detalles Bibliográficos
Autores principales: van Ingen, Gijs, Li, Jin, Goedegebure, André, Pandey, Rahul, Li, Yun Rose, March, Michael E., Jaddoe, Vincent W. V., Bakay, Marina, Mentch, Frank D., Thomas, Kelly, Wei, Zhi, Chang, Xiao, Hain, Heather S., Uitterlinden, André G., Moll, Henriette A., van Duijn, Cornelia M., Rivadeneira, Fernando, Raat, Hein, Baatenburg de Jong, Robert J., Sleiman, Patrick M., van der Schroeff, Marc P., Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052699/
https://www.ncbi.nlm.nih.gov/pubmed/27677580
http://dx.doi.org/10.1038/ncomms12792
Descripción
Sumario:Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, P(meta)=2.15 × 10(−09)), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10(−06)), and further show it is an eQTL for FNDC1 (P=9.3 × 10(−05)). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.

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