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No difference found in time to publication by statistical significance of trial results: a methodological review

OBJECTIVE: Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DE...

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Autores principales: Jefferson, L, Fairhurst, C, Cooper, E, Hewitt, C, Torgerson, T, Cook, L, Tharmanathan, P, Cockayne, S, Torgerson, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052771/
https://www.ncbi.nlm.nih.gov/pubmed/27757242
http://dx.doi.org/10.1177/2054270416649283
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author Jefferson, L
Fairhurst, C
Cooper, E
Hewitt, C
Torgerson, T
Cook, L
Tharmanathan, P
Cockayne, S
Torgerson, D
author_facet Jefferson, L
Fairhurst, C
Cooper, E
Hewitt, C
Torgerson, T
Cook, L
Tharmanathan, P
Cockayne, S
Torgerson, D
author_sort Jefferson, L
collection PubMed
description OBJECTIVE: Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DESIGN: Literature searches were carried out in four general medical journals from June 2013 to June 2014 inclusive (BMJ, JAMA, the Lancet and the New England Journal of Medicine). SETTING: Methodological review of four general medical journals. PARTICIPANTS: Original research articles presenting the primary analyses from phase 2, 3 and 4 parallel-group randomised controlled trials were included. MAIN OUTCOME MEASURES: Time from trial completion to publication. RESULTS: The median time from trial completion to publication was 431 days (n = 208, interquartile range 278–618). A multivariable adjusted Cox model found no statistically significant difference in time to publication for trials reporting positive or negative results (hazard ratio: 0.86, 95% CI 0.64 to 1.16, p = 0.32). CONCLUSION: In contrast to previous studies, this review did not demonstrate the presence of time-lag bias in time to publication. This may be a result of these articles being published in four high-impact general medical journals that may be more inclined to publish rapidly, whatever the findings. Further research is needed to explore the presence of time-lag bias in lower quality studies and lower impact journals.
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spelling pubmed-50527712016-10-18 No difference found in time to publication by statistical significance of trial results: a methodological review Jefferson, L Fairhurst, C Cooper, E Hewitt, C Torgerson, T Cook, L Tharmanathan, P Cockayne, S Torgerson, D JRSM Open Research OBJECTIVE: Time-lag from study completion to publication is a potential source of publication bias in randomised controlled trials. This study sought to update the evidence base by identifying the effect of the statistical significance of research findings on time to publication of trial results. DESIGN: Literature searches were carried out in four general medical journals from June 2013 to June 2014 inclusive (BMJ, JAMA, the Lancet and the New England Journal of Medicine). SETTING: Methodological review of four general medical journals. PARTICIPANTS: Original research articles presenting the primary analyses from phase 2, 3 and 4 parallel-group randomised controlled trials were included. MAIN OUTCOME MEASURES: Time from trial completion to publication. RESULTS: The median time from trial completion to publication was 431 days (n = 208, interquartile range 278–618). A multivariable adjusted Cox model found no statistically significant difference in time to publication for trials reporting positive or negative results (hazard ratio: 0.86, 95% CI 0.64 to 1.16, p = 0.32). CONCLUSION: In contrast to previous studies, this review did not demonstrate the presence of time-lag bias in time to publication. This may be a result of these articles being published in four high-impact general medical journals that may be more inclined to publish rapidly, whatever the findings. Further research is needed to explore the presence of time-lag bias in lower quality studies and lower impact journals. SAGE Publications 2016-10-04 /pmc/articles/PMC5052771/ /pubmed/27757242 http://dx.doi.org/10.1177/2054270416649283 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research
Jefferson, L
Fairhurst, C
Cooper, E
Hewitt, C
Torgerson, T
Cook, L
Tharmanathan, P
Cockayne, S
Torgerson, D
No difference found in time to publication by statistical significance of trial results: a methodological review
title No difference found in time to publication by statistical significance of trial results: a methodological review
title_full No difference found in time to publication by statistical significance of trial results: a methodological review
title_fullStr No difference found in time to publication by statistical significance of trial results: a methodological review
title_full_unstemmed No difference found in time to publication by statistical significance of trial results: a methodological review
title_short No difference found in time to publication by statistical significance of trial results: a methodological review
title_sort no difference found in time to publication by statistical significance of trial results: a methodological review
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052771/
https://www.ncbi.nlm.nih.gov/pubmed/27757242
http://dx.doi.org/10.1177/2054270416649283
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