Cargando…

Acute Dystonia After Single Dose of Bupropion

Bupropion is an antidepressant that is effective in the treatment of major depressive disorders, smoking cessation, and sexual side effects of selective serotonin reuptake inhibitors. Acute dystonia is characterized by prolonged muscle contraction often represented by spasms of the head and neck mus...

Descripción completa

Detalles Bibliográficos
Autores principales: Elyasi, Forouzan, Mahtiyan, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052961/
https://www.ncbi.nlm.nih.gov/pubmed/27833231
http://dx.doi.org/10.4103/0253-7176.191384
_version_ 1782458321180033024
author Elyasi, Forouzan
Mahtiyan, Elham
author_facet Elyasi, Forouzan
Mahtiyan, Elham
author_sort Elyasi, Forouzan
collection PubMed
description Bupropion is an antidepressant that is effective in the treatment of major depressive disorders, smoking cessation, and sexual side effects of selective serotonin reuptake inhibitors. Acute dystonia is characterized by prolonged muscle contraction often represented by spasms of the head and neck muscles as well as occasional jaw clenching and temporomandibular joint syndrome. Although it is believed that dystonia is the result of an abnormality of the basal ganglia, its pathophysiology is still unclear. A few cases of dystonia resulting from bupropion have been reported in prior research papers. This case report discusses a patient who had a neck spasm painful enough to wake him up and dystonic distortion after taking only one dose of 75 mg bupropion. The patient was a young 34-year-old man with a diagnosis of obsessive-compulsive disorder treated with 60 mg fluoxetine. Bupropion was added to his medications because of sexual side effects caused by the fluoxetine. It seems that we must be careful to watch for dystonic symptoms when bupropion is mixed with other drugs that affect serotonin reuptake. Although dystonia is a rare side effect of bupropion, physicians should be aware of it and manage it if it occurs.
format Online
Article
Text
id pubmed-5052961
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-50529612016-11-10 Acute Dystonia After Single Dose of Bupropion Elyasi, Forouzan Mahtiyan, Elham Indian J Psychol Med Case Report Bupropion is an antidepressant that is effective in the treatment of major depressive disorders, smoking cessation, and sexual side effects of selective serotonin reuptake inhibitors. Acute dystonia is characterized by prolonged muscle contraction often represented by spasms of the head and neck muscles as well as occasional jaw clenching and temporomandibular joint syndrome. Although it is believed that dystonia is the result of an abnormality of the basal ganglia, its pathophysiology is still unclear. A few cases of dystonia resulting from bupropion have been reported in prior research papers. This case report discusses a patient who had a neck spasm painful enough to wake him up and dystonic distortion after taking only one dose of 75 mg bupropion. The patient was a young 34-year-old man with a diagnosis of obsessive-compulsive disorder treated with 60 mg fluoxetine. Bupropion was added to his medications because of sexual side effects caused by the fluoxetine. It seems that we must be careful to watch for dystonic symptoms when bupropion is mixed with other drugs that affect serotonin reuptake. Although dystonia is a rare side effect of bupropion, physicians should be aware of it and manage it if it occurs. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5052961/ /pubmed/27833231 http://dx.doi.org/10.4103/0253-7176.191384 Text en Copyright: © 2016 Indian Psychiatric Society http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Elyasi, Forouzan
Mahtiyan, Elham
Acute Dystonia After Single Dose of Bupropion
title Acute Dystonia After Single Dose of Bupropion
title_full Acute Dystonia After Single Dose of Bupropion
title_fullStr Acute Dystonia After Single Dose of Bupropion
title_full_unstemmed Acute Dystonia After Single Dose of Bupropion
title_short Acute Dystonia After Single Dose of Bupropion
title_sort acute dystonia after single dose of bupropion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052961/
https://www.ncbi.nlm.nih.gov/pubmed/27833231
http://dx.doi.org/10.4103/0253-7176.191384
work_keys_str_mv AT elyasiforouzan acutedystoniaaftersingledoseofbupropion
AT mahtiyanelham acutedystoniaaftersingledoseofbupropion