Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases

Amisulpride, recently introduced atypical antipsychotic, is well-known for its broad spectrum effectiveness and lower profile for extrapyramidal side effects (EPS). Its selective affinity for dopamine receptors in the limbic structures, but not in the striatum, leads to a low risk of extrapyramidal...

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Autores principales: Kumar, Pattath Narayanan Suresh, Gopalakrishnan, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052967/
https://www.ncbi.nlm.nih.gov/pubmed/27833237
http://dx.doi.org/10.4103/0253-7176.191391
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author Kumar, Pattath Narayanan Suresh
Gopalakrishnan, Arun
author_facet Kumar, Pattath Narayanan Suresh
Gopalakrishnan, Arun
author_sort Kumar, Pattath Narayanan Suresh
collection PubMed
description Amisulpride, recently introduced atypical antipsychotic, is well-known for its broad spectrum effectiveness and lower profile for extrapyramidal side effects (EPS). Its selective affinity for dopamine receptors in the limbic structures, but not in the striatum, leads to a low risk of extrapyramidal side effects. Here, we report two cases of EPS associated with lower dose of amisulpride. The proposed mechanism for its causation is also discussed. Authors invite more studies, specifically from the Indian context to find out the incidence of EPS and other associated side effects.
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spelling pubmed-50529672016-11-10 Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases Kumar, Pattath Narayanan Suresh Gopalakrishnan, Arun Indian J Psychol Med Case Report Amisulpride, recently introduced atypical antipsychotic, is well-known for its broad spectrum effectiveness and lower profile for extrapyramidal side effects (EPS). Its selective affinity for dopamine receptors in the limbic structures, but not in the striatum, leads to a low risk of extrapyramidal side effects. Here, we report two cases of EPS associated with lower dose of amisulpride. The proposed mechanism for its causation is also discussed. Authors invite more studies, specifically from the Indian context to find out the incidence of EPS and other associated side effects. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5052967/ /pubmed/27833237 http://dx.doi.org/10.4103/0253-7176.191391 Text en Copyright: © 2016 Indian Psychiatric Society http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Kumar, Pattath Narayanan Suresh
Gopalakrishnan, Arun
Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases
title Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases
title_full Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases
title_fullStr Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases
title_full_unstemmed Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases
title_short Extrapyramidal Side Effects with Low Dose Amisulpride: A Report of Two Cases
title_sort extrapyramidal side effects with low dose amisulpride: a report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052967/
https://www.ncbi.nlm.nih.gov/pubmed/27833237
http://dx.doi.org/10.4103/0253-7176.191391
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