Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone

Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagul...

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Autores principales: Anoop, Parameswaran, Malmande, Vithal, Prakash Kumar, M. N., Rao, Naveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053005/
https://www.ncbi.nlm.nih.gov/pubmed/27833295
http://dx.doi.org/10.4103/0970-0358.191307
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author Anoop, Parameswaran
Malmande, Vithal
Prakash Kumar, M. N.
Rao, Naveen
author_facet Anoop, Parameswaran
Malmande, Vithal
Prakash Kumar, M. N.
Rao, Naveen
author_sort Anoop, Parameswaran
collection PubMed
description Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagulable state due to protein-S deficiency in addition to long-term exogenous testosterone administration. Role of thrombophilia testing, thrombogenic potential of testosterone and the need for therapeutic perioperative anti-coagulation in such situations are described here.
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spelling pubmed-50530052016-11-10 Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone Anoop, Parameswaran Malmande, Vithal Prakash Kumar, M. N. Rao, Naveen Indian J Plast Surg Case Report Flap failure from microvascular thrombotic occlusion is a rare but significant cause for unsuccessful reconstructive surgery. We encountered thrombosis of arteriovenous loop in a patient undergoing phallus reconstruction. Further investigations revealed underlying previously asymptomatic hypercoagulable state due to protein-S deficiency in addition to long-term exogenous testosterone administration. Role of thrombophilia testing, thrombogenic potential of testosterone and the need for therapeutic perioperative anti-coagulation in such situations are described here. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5053005/ /pubmed/27833295 http://dx.doi.org/10.4103/0970-0358.191307 Text en Copyright: © Indian Journal of Plastic Surgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Anoop, Parameswaran
Malmande, Vithal
Prakash Kumar, M. N.
Rao, Naveen
Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone
title Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone
title_full Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone
title_fullStr Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone
title_full_unstemmed Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone
title_short Successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-S deficiency and exogenous testosterone
title_sort successful penile reconstruction following prior arteriovenous loop thrombosis due to undiagnosed protein-s deficiency and exogenous testosterone
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053005/
https://www.ncbi.nlm.nih.gov/pubmed/27833295
http://dx.doi.org/10.4103/0970-0358.191307
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