A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation

In January 2003, a 55-year old, non-smoking woman visited our hospital to undergo treatment for T4N0M0 pulmonary adenocarcinoma of the left lung. Until death in October 2015, she received over 20 lines of treatment including a second line therapy with gefitinib, which showed long response. In March...

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Autores principales: Imamura, Fumio, Inoue, Takako, Kimura, Madoka, Nishino, Kazumi, Kumagai, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053035/
https://www.ncbi.nlm.nih.gov/pubmed/27747151
http://dx.doi.org/10.1016/j.rmcr.2016.09.002
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author Imamura, Fumio
Inoue, Takako
Kimura, Madoka
Nishino, Kazumi
Kumagai, Toru
author_facet Imamura, Fumio
Inoue, Takako
Kimura, Madoka
Nishino, Kazumi
Kumagai, Toru
author_sort Imamura, Fumio
collection PubMed
description In January 2003, a 55-year old, non-smoking woman visited our hospital to undergo treatment for T4N0M0 pulmonary adenocarcinoma of the left lung. Until death in October 2015, she received over 20 lines of treatment including a second line therapy with gefitinib, which showed long response. In March 2014, she noticed the left axillar lymph node swelling. Aspiration cytology of the lymph node revealed the presence of adenocarcinoma harboring EGFR exon 19 deletion (Ex19del) but not T790M. Concomitant ALK translocation of variant 1 was also detected. Crizotinib and alectinib showed marked decrease of serum CEA value from 731.9 to 122.2 and moderate radiologic response. In contrast, both Ex19del and T790M, but not ALK translocation, were detected in the metastasis to the left anterior chest wall.
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spelling pubmed-50530352016-10-14 A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation Imamura, Fumio Inoue, Takako Kimura, Madoka Nishino, Kazumi Kumagai, Toru Respir Med Case Rep Case Report In January 2003, a 55-year old, non-smoking woman visited our hospital to undergo treatment for T4N0M0 pulmonary adenocarcinoma of the left lung. Until death in October 2015, she received over 20 lines of treatment including a second line therapy with gefitinib, which showed long response. In March 2014, she noticed the left axillar lymph node swelling. Aspiration cytology of the lymph node revealed the presence of adenocarcinoma harboring EGFR exon 19 deletion (Ex19del) but not T790M. Concomitant ALK translocation of variant 1 was also detected. Crizotinib and alectinib showed marked decrease of serum CEA value from 731.9 to 122.2 and moderate radiologic response. In contrast, both Ex19del and T790M, but not ALK translocation, were detected in the metastasis to the left anterior chest wall. Elsevier 2016-09-30 /pmc/articles/PMC5053035/ /pubmed/27747151 http://dx.doi.org/10.1016/j.rmcr.2016.09.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Imamura, Fumio
Inoue, Takako
Kimura, Madoka
Nishino, Kazumi
Kumagai, Toru
A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
title A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
title_full A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
title_fullStr A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
title_full_unstemmed A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
title_short A long-term survivor of non-small-cell lung cancer harboring concomitant EGFR mutation and ALK translocation
title_sort long-term survivor of non-small-cell lung cancer harboring concomitant egfr mutation and alk translocation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053035/
https://www.ncbi.nlm.nih.gov/pubmed/27747151
http://dx.doi.org/10.1016/j.rmcr.2016.09.002
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