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Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience

BACKGROUND: Hyponatremia developing in hypothyroid patients has been encountered in clinical practice; however, its prevalence has not been well established. METHODS: Thirty patients diagnosed with differentiated thyroid cancer, rendered hypothyroid after surgery and levothyroxine withdrawal, and wh...

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Autores principales: Dayrit, Juan Carlo P., Cunanan, Elaine C., Kho, Sjoberg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053053/
https://www.ncbi.nlm.nih.gov/pubmed/27546873
http://dx.doi.org/10.3803/EnM.2016.31.3.410
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author Dayrit, Juan Carlo P.
Cunanan, Elaine C.
Kho, Sjoberg A.
author_facet Dayrit, Juan Carlo P.
Cunanan, Elaine C.
Kho, Sjoberg A.
author_sort Dayrit, Juan Carlo P.
collection PubMed
description BACKGROUND: Hyponatremia developing in hypothyroid patients has been encountered in clinical practice; however, its prevalence has not been well established. METHODS: Thirty patients diagnosed with differentiated thyroid cancer, rendered hypothyroid after surgery and levothyroxine withdrawal, and who are for radioactive iodine (RAI) ablation were included. Serum sodium concentrations were measured twice, at the time of admission for RAI ablation, and before discharge after increased oral fluid intake. The outcome measures were to determine the prevalence of hyponatremia among hypothyroid patients prior to RAI ablation and after oral hydration post-RAI, and to correlate the serum sodium levels pre-RAI and post-RAI with thyroid-stimulating hormone (TSH) concentration and age. RESULTS: Thirty patients were included, with ages from 23 to 65 years old (median, 40). Two patients (6.7%) were hyponatremic prior to RAI ablation, and eight patients (26.7%) had mild hyponatremia (130 to 134 mEq/L) after RAI and hydration. There was no significant correlation between TSH levels and serum sodium levels prior to or after RAI. There was also no significant correlation between pre- and post-RAI sodium concentration and age. CONCLUSIONS: The prevalence of hyponatremia pre-RAI was 6.7%, and 26.7% post-RAI. No significant correlation was noted between TSH concentration and age on pre- or post-RAI sodium concentrations. Routine measurement of serum sodium post-RAI/isolation is still not advised. Measurement of sodium post-RAI may be considered in patients who are elderly, with comorbid conditions or on medications.
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spelling pubmed-50530532016-10-07 Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience Dayrit, Juan Carlo P. Cunanan, Elaine C. Kho, Sjoberg A. Endocrinol Metab (Seoul) Original Article BACKGROUND: Hyponatremia developing in hypothyroid patients has been encountered in clinical practice; however, its prevalence has not been well established. METHODS: Thirty patients diagnosed with differentiated thyroid cancer, rendered hypothyroid after surgery and levothyroxine withdrawal, and who are for radioactive iodine (RAI) ablation were included. Serum sodium concentrations were measured twice, at the time of admission for RAI ablation, and before discharge after increased oral fluid intake. The outcome measures were to determine the prevalence of hyponatremia among hypothyroid patients prior to RAI ablation and after oral hydration post-RAI, and to correlate the serum sodium levels pre-RAI and post-RAI with thyroid-stimulating hormone (TSH) concentration and age. RESULTS: Thirty patients were included, with ages from 23 to 65 years old (median, 40). Two patients (6.7%) were hyponatremic prior to RAI ablation, and eight patients (26.7%) had mild hyponatremia (130 to 134 mEq/L) after RAI and hydration. There was no significant correlation between TSH levels and serum sodium levels prior to or after RAI. There was also no significant correlation between pre- and post-RAI sodium concentration and age. CONCLUSIONS: The prevalence of hyponatremia pre-RAI was 6.7%, and 26.7% post-RAI. No significant correlation was noted between TSH concentration and age on pre- or post-RAI sodium concentrations. Routine measurement of serum sodium post-RAI/isolation is still not advised. Measurement of sodium post-RAI may be considered in patients who are elderly, with comorbid conditions or on medications. Korean Endocrine Society 2016-09 2016-08-17 /pmc/articles/PMC5053053/ /pubmed/27546873 http://dx.doi.org/10.3803/EnM.2016.31.3.410 Text en Copyright © 2016 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dayrit, Juan Carlo P.
Cunanan, Elaine C.
Kho, Sjoberg A.
Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
title Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
title_full Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
title_fullStr Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
title_full_unstemmed Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
title_short Prevalence of Hyponatremia in Hypothyroid Patients during Radioactive (131)I Ablation for Differentiated Thyroid Cancer: Single Institution Experience
title_sort prevalence of hyponatremia in hypothyroid patients during radioactive (131)i ablation for differentiated thyroid cancer: single institution experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053053/
https://www.ncbi.nlm.nih.gov/pubmed/27546873
http://dx.doi.org/10.3803/EnM.2016.31.3.410
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