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Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)

The drug yielding potential of turmeric (Curcuma longa L.) is largely due to the presence of phyto-constituent ‘curcumin.’ Curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. Lack of requisite high curcumin containing genotypes and...

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Autores principales: Akbar, Abdul, Kuanar, Ananya, Joshi, Raj K., Sandeep, I. S., Mohanty, Sujata, Naik, Pradeep K., Mishra, Antaryami, Nayak, Sanghamitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053083/
https://www.ncbi.nlm.nih.gov/pubmed/27766103
http://dx.doi.org/10.3389/fpls.2016.01507
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author Akbar, Abdul
Kuanar, Ananya
Joshi, Raj K.
Sandeep, I. S.
Mohanty, Sujata
Naik, Pradeep K.
Mishra, Antaryami
Nayak, Sanghamitra
author_facet Akbar, Abdul
Kuanar, Ananya
Joshi, Raj K.
Sandeep, I. S.
Mohanty, Sujata
Naik, Pradeep K.
Mishra, Antaryami
Nayak, Sanghamitra
author_sort Akbar, Abdul
collection PubMed
description The drug yielding potential of turmeric (Curcuma longa L.) is largely due to the presence of phyto-constituent ‘curcumin.’ Curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. Lack of requisite high curcumin containing genotypes and variation in the curcumin content of turmeric at different agro climatic regions are the major stumbling blocks in commercial production of turmeric. Curcumin content of turmeric is greatly influenced by environmental factors. Hence, a prediction model based on artificial neural network (ANN) was developed to map genome environment interaction basing on curcumin content, soli and climatic factors from different agroclimatic regions for prediction of maximum curcumin content at various sites to facilitate the selection of suitable region for commercial cultivation of turmeric. The ANN model was developed and tested using a data set of 119 generated by collecting samples from 8 different agroclimatic regions of Odisha. The curcumin content from these samples was measured that varied from 7.2% to 0.4%. The ANN model was trained with 11 parameters of soil and climatic factors as input and curcumin content as output. The results showed that feed-forward ANN model with 8 nodes (MLFN-8) was the most suitable one with R(2) value of 0.91. Sensitivity analysis revealed that minimum relative humidity, altitude, soil nitrogen content and soil pH had greater effect on curcumin content. This ANN model has shown proven efficiency for predicting and optimizing the curcumin content at a specific site.
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spelling pubmed-50530832016-10-20 Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.) Akbar, Abdul Kuanar, Ananya Joshi, Raj K. Sandeep, I. S. Mohanty, Sujata Naik, Pradeep K. Mishra, Antaryami Nayak, Sanghamitra Front Plant Sci Plant Science The drug yielding potential of turmeric (Curcuma longa L.) is largely due to the presence of phyto-constituent ‘curcumin.’ Curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. Lack of requisite high curcumin containing genotypes and variation in the curcumin content of turmeric at different agro climatic regions are the major stumbling blocks in commercial production of turmeric. Curcumin content of turmeric is greatly influenced by environmental factors. Hence, a prediction model based on artificial neural network (ANN) was developed to map genome environment interaction basing on curcumin content, soli and climatic factors from different agroclimatic regions for prediction of maximum curcumin content at various sites to facilitate the selection of suitable region for commercial cultivation of turmeric. The ANN model was developed and tested using a data set of 119 generated by collecting samples from 8 different agroclimatic regions of Odisha. The curcumin content from these samples was measured that varied from 7.2% to 0.4%. The ANN model was trained with 11 parameters of soil and climatic factors as input and curcumin content as output. The results showed that feed-forward ANN model with 8 nodes (MLFN-8) was the most suitable one with R(2) value of 0.91. Sensitivity analysis revealed that minimum relative humidity, altitude, soil nitrogen content and soil pH had greater effect on curcumin content. This ANN model has shown proven efficiency for predicting and optimizing the curcumin content at a specific site. Frontiers Media S.A. 2016-10-06 /pmc/articles/PMC5053083/ /pubmed/27766103 http://dx.doi.org/10.3389/fpls.2016.01507 Text en Copyright © 2016 Akbar, Kuanar, Joshi, Sandeep, Mohanty, Naik, Mishra and Nayak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Akbar, Abdul
Kuanar, Ananya
Joshi, Raj K.
Sandeep, I. S.
Mohanty, Sujata
Naik, Pradeep K.
Mishra, Antaryami
Nayak, Sanghamitra
Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)
title Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)
title_full Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)
title_fullStr Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)
title_full_unstemmed Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)
title_short Development of Prediction Model and Experimental Validation in Predicting the Curcumin Content of Turmeric (Curcuma longa L.)
title_sort development of prediction model and experimental validation in predicting the curcumin content of turmeric (curcuma longa l.)
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053083/
https://www.ncbi.nlm.nih.gov/pubmed/27766103
http://dx.doi.org/10.3389/fpls.2016.01507
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