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Thoracic epidural analgesia reduces gastric microcirculation in the pig

BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig. METHODS: Splanchnic microcirculation was assess...

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Autores principales: Ambrus, Rikard, Strandby, Rune B., Secher, Niels H., Rünitz, Kim, Svendsen, Morten B. S., Petersen, Lonnie G., Achiam, Michael P., Svendsen, Lars B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053122/
https://www.ncbi.nlm.nih.gov/pubmed/27716081
http://dx.doi.org/10.1186/s12871-016-0256-4
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author Ambrus, Rikard
Strandby, Rune B.
Secher, Niels H.
Rünitz, Kim
Svendsen, Morten B. S.
Petersen, Lonnie G.
Achiam, Michael P.
Svendsen, Lars B.
author_facet Ambrus, Rikard
Strandby, Rune B.
Secher, Niels H.
Rünitz, Kim
Svendsen, Morten B. S.
Petersen, Lonnie G.
Achiam, Michael P.
Svendsen, Lars B.
author_sort Ambrus, Rikard
collection PubMed
description BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig. METHODS: Splanchnic microcirculation was assessed in nine pigs prior to and 15 and 30 min after induction of TEA. Regional blood flow was assessed by neutron activated microspheres and changes in microcirculation by laser speckle contrast imaging (LSCI). RESULTS: As assessed by LSCI 15 min following TEA, gastric arteriolar flow decreased by 22 % at the antrum (p = 0.020) and by 19 % at the corpus (p = 0.029) of the stomach. In parallel, the microcirculation decreased by 19 % at the antrum (p = 0.015) and by 20 % at the corpus (p = 0.028). Reduced arteriolar flow and microcirculation at the antrum was confirmed by a reduction in microsphere assessed regional blood flow 30 min following induction of TEA (p = 0.048). These manifestations took place along with a drop in systolic blood pressure (p = 0.030), but with no significant change in mean arterial pressure, cardiac output, or heart rate. CONCLUSION: The results indicate that TEA may have an adverse effect on gastric arteriolar blood flow and microcirculation. LSCI is a non-touch technique and displays changes in blood flow in real-time and may be important for further evaluation of the concern regarding the effect of thoracic epidural anesthesia on gastric microcirculation in humans. TRIAL REGISTRATIONS: Not applicable, non-human study.
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spelling pubmed-50531222016-10-06 Thoracic epidural analgesia reduces gastric microcirculation in the pig Ambrus, Rikard Strandby, Rune B. Secher, Niels H. Rünitz, Kim Svendsen, Morten B. S. Petersen, Lonnie G. Achiam, Michael P. Svendsen, Lars B. BMC Anesthesiol Research Article BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig. METHODS: Splanchnic microcirculation was assessed in nine pigs prior to and 15 and 30 min after induction of TEA. Regional blood flow was assessed by neutron activated microspheres and changes in microcirculation by laser speckle contrast imaging (LSCI). RESULTS: As assessed by LSCI 15 min following TEA, gastric arteriolar flow decreased by 22 % at the antrum (p = 0.020) and by 19 % at the corpus (p = 0.029) of the stomach. In parallel, the microcirculation decreased by 19 % at the antrum (p = 0.015) and by 20 % at the corpus (p = 0.028). Reduced arteriolar flow and microcirculation at the antrum was confirmed by a reduction in microsphere assessed regional blood flow 30 min following induction of TEA (p = 0.048). These manifestations took place along with a drop in systolic blood pressure (p = 0.030), but with no significant change in mean arterial pressure, cardiac output, or heart rate. CONCLUSION: The results indicate that TEA may have an adverse effect on gastric arteriolar blood flow and microcirculation. LSCI is a non-touch technique and displays changes in blood flow in real-time and may be important for further evaluation of the concern regarding the effect of thoracic epidural anesthesia on gastric microcirculation in humans. TRIAL REGISTRATIONS: Not applicable, non-human study. BioMed Central 2016-10-06 /pmc/articles/PMC5053122/ /pubmed/27716081 http://dx.doi.org/10.1186/s12871-016-0256-4 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ambrus, Rikard
Strandby, Rune B.
Secher, Niels H.
Rünitz, Kim
Svendsen, Morten B. S.
Petersen, Lonnie G.
Achiam, Michael P.
Svendsen, Lars B.
Thoracic epidural analgesia reduces gastric microcirculation in the pig
title Thoracic epidural analgesia reduces gastric microcirculation in the pig
title_full Thoracic epidural analgesia reduces gastric microcirculation in the pig
title_fullStr Thoracic epidural analgesia reduces gastric microcirculation in the pig
title_full_unstemmed Thoracic epidural analgesia reduces gastric microcirculation in the pig
title_short Thoracic epidural analgesia reduces gastric microcirculation in the pig
title_sort thoracic epidural analgesia reduces gastric microcirculation in the pig
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053122/
https://www.ncbi.nlm.nih.gov/pubmed/27716081
http://dx.doi.org/10.1186/s12871-016-0256-4
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