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Vitamin D, vitamin A, the primary melanoma transcriptome and survival
Survival from melanoma is influenced by several, well‐established clinical and histopathological factors, e.g. age, Breslow thickness and microscopic ulceration. We (the Section of Epidemiology and Biostatistics, University of Leeds) have carried out research to better understand the biological basi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053247/ https://www.ncbi.nlm.nih.gov/pubmed/27667313 http://dx.doi.org/10.1111/bjd.14919 |
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author | O'Shea, S.J. Davies, J.R. Newton‐Bishop, J.A. |
author_facet | O'Shea, S.J. Davies, J.R. Newton‐Bishop, J.A. |
author_sort | O'Shea, S.J. |
collection | PubMed |
description | Survival from melanoma is influenced by several, well‐established clinical and histopathological factors, e.g. age, Breslow thickness and microscopic ulceration. We (the Section of Epidemiology and Biostatistics, University of Leeds) have carried out research to better understand the biological basis for these observations. Preliminary results indicated a protective role for vitamin D in melanoma relapse and that higher vitamin D was associated with thinner primary melanomas. Funding from the British Skin Foundation enabled JNB to establish a study of the effects of vitamin A in melanoma. The results suggested that vitamin A could reduce the protective effect of vitamin D in terms of overall survival. Therefore, we propose that vitamin D(3) supplementation alone might be preferable to combined multivitamin preparations, where vitamin D supplementation is deemed to be appropriate. Proving a causal link between vitamin D and melanoma‐specific survival is challenging. We have shown limited evidence of causation in a Mendelian randomization experiment (described in more detail later). Recent work in Leeds has also shown that higher vitamin D may be protective for microscopic ulceration. Taken together, vitamin D appears to be associated with less aggressive primary melanomas and may itself influence outcome. We continue to explore the role of vitamin D in melanoma survival and the optimum levels that might be crucial. |
format | Online Article Text |
id | pubmed-5053247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50532472016-10-19 Vitamin D, vitamin A, the primary melanoma transcriptome and survival O'Shea, S.J. Davies, J.R. Newton‐Bishop, J.A. Br J Dermatol British Skin Foundation, Skin Deep ‐ 20 Years of Research, 20th Anniversary Conference, 13th October 2016, Royal College of Physicians, London, U.K. Publication of this supplement was supported by Stiefel, a GSK company Survival from melanoma is influenced by several, well‐established clinical and histopathological factors, e.g. age, Breslow thickness and microscopic ulceration. We (the Section of Epidemiology and Biostatistics, University of Leeds) have carried out research to better understand the biological basis for these observations. Preliminary results indicated a protective role for vitamin D in melanoma relapse and that higher vitamin D was associated with thinner primary melanomas. Funding from the British Skin Foundation enabled JNB to establish a study of the effects of vitamin A in melanoma. The results suggested that vitamin A could reduce the protective effect of vitamin D in terms of overall survival. Therefore, we propose that vitamin D(3) supplementation alone might be preferable to combined multivitamin preparations, where vitamin D supplementation is deemed to be appropriate. Proving a causal link between vitamin D and melanoma‐specific survival is challenging. We have shown limited evidence of causation in a Mendelian randomization experiment (described in more detail later). Recent work in Leeds has also shown that higher vitamin D may be protective for microscopic ulceration. Taken together, vitamin D appears to be associated with less aggressive primary melanomas and may itself influence outcome. We continue to explore the role of vitamin D in melanoma survival and the optimum levels that might be crucial. John Wiley and Sons Inc. 2016-09-26 2016-10 /pmc/articles/PMC5053247/ /pubmed/27667313 http://dx.doi.org/10.1111/bjd.14919 Text en © 2016 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | British Skin Foundation, Skin Deep ‐ 20 Years of Research, 20th Anniversary Conference, 13th October 2016, Royal College of Physicians, London, U.K. Publication of this supplement was supported by Stiefel, a GSK company O'Shea, S.J. Davies, J.R. Newton‐Bishop, J.A. Vitamin D, vitamin A, the primary melanoma transcriptome and survival |
title | Vitamin D, vitamin A, the primary melanoma transcriptome and survival |
title_full | Vitamin D, vitamin A, the primary melanoma transcriptome and survival |
title_fullStr | Vitamin D, vitamin A, the primary melanoma transcriptome and survival |
title_full_unstemmed | Vitamin D, vitamin A, the primary melanoma transcriptome and survival |
title_short | Vitamin D, vitamin A, the primary melanoma transcriptome and survival |
title_sort | vitamin d, vitamin a, the primary melanoma transcriptome and survival |
topic | British Skin Foundation, Skin Deep ‐ 20 Years of Research, 20th Anniversary Conference, 13th October 2016, Royal College of Physicians, London, U.K. Publication of this supplement was supported by Stiefel, a GSK company |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053247/ https://www.ncbi.nlm.nih.gov/pubmed/27667313 http://dx.doi.org/10.1111/bjd.14919 |
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