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Proteolysis of plasminogen activator inhibitor‐1 by Yersinia pestis remodulates the host environment to promote virulence
ESSENTIALS: Effect of plasminogen activator inhibitor (PAI)‐1 on plague and its Y. pestis cleavage is unknown. An intranasal mouse model of infection was used to determine the role of PAI‐1 in pneumonic plague. PAI‐1 is cleaved and inactivated by the Pla protease of Y. pestis in the lung airspace. P...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053288/ https://www.ncbi.nlm.nih.gov/pubmed/27377187 http://dx.doi.org/10.1111/jth.13408 |