Novel N‐allyl/propargyl tetrahydroquinolines: Synthesis via Three‐component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors

New N‐allyl/propargyl 4‐substituted 1,2,3,4‐tetrahydroquinolines derivatives were efficiently synthesized using acid‐catalyzed three components cationic imino Diels–Alder reaction (70–95%). All compounds were tested in vitro as dual acetylcholinesterase and butyryl‐cholinesterase inhibitors and thei...

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Detalles Bibliográficos
Autores principales: Rodríguez, Yeray A., Gutiérrez, Margarita, Ramírez, David, Alzate‐Morales, Jans, Bernal, Cristian C., Güiza, Fausto M., Romero Bohórquez, Arnold R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053295/
https://www.ncbi.nlm.nih.gov/pubmed/27085663
http://dx.doi.org/10.1111/cbdd.12773

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