Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens

T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin‐4, exhibit Th17 polarization and cross‐react with a homologous sequence of a Clostridium perfringens adenosine triphosphate‐binding cassette transporter. Therefore, this commensal microbe might...

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Autores principales: Cree, Bruce A. C., Spencer, Collin M., Varrin‐Doyer, Michel, Baranzini, Sergio E., Zamvil, Scott S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053302/
https://www.ncbi.nlm.nih.gov/pubmed/27398819
http://dx.doi.org/10.1002/ana.24718
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author Cree, Bruce A. C.
Spencer, Collin M.
Varrin‐Doyer, Michel
Baranzini, Sergio E.
Zamvil, Scott S.
author_facet Cree, Bruce A. C.
Spencer, Collin M.
Varrin‐Doyer, Michel
Baranzini, Sergio E.
Zamvil, Scott S.
author_sort Cree, Bruce A. C.
collection PubMed
description T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin‐4, exhibit Th17 polarization and cross‐react with a homologous sequence of a Clostridium perfringens adenosine triphosphate‐binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and 16 multiple sclerosis patients. A significant difference in the abundance of several microbial communities was observed between NMO and HC (Adonis test, p = 0.001). Strikingly, C. perfringens was overrepresented in NMO (p = 5.24 × 10(−8)). These observations support a potential role for C. perfringens in NMO pathogenesis. Ann Neurol 2016;80:443–447
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spelling pubmed-50533022016-10-19 Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens Cree, Bruce A. C. Spencer, Collin M. Varrin‐Doyer, Michel Baranzini, Sergio E. Zamvil, Scott S. Ann Neurol Brief Communications T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin‐4, exhibit Th17 polarization and cross‐react with a homologous sequence of a Clostridium perfringens adenosine triphosphate‐binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and 16 multiple sclerosis patients. A significant difference in the abundance of several microbial communities was observed between NMO and HC (Adonis test, p = 0.001). Strikingly, C. perfringens was overrepresented in NMO (p = 5.24 × 10(−8)). These observations support a potential role for C. perfringens in NMO pathogenesis. Ann Neurol 2016;80:443–447 John Wiley and Sons Inc. 2016-08-04 2016-09 /pmc/articles/PMC5053302/ /pubmed/27398819 http://dx.doi.org/10.1002/ana.24718 Text en © 2016 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Cree, Bruce A. C.
Spencer, Collin M.
Varrin‐Doyer, Michel
Baranzini, Sergio E.
Zamvil, Scott S.
Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
title Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
title_full Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
title_fullStr Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
title_full_unstemmed Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
title_short Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
title_sort gut microbiome analysis in neuromyelitis optica reveals overabundance of clostridium perfringens
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053302/
https://www.ncbi.nlm.nih.gov/pubmed/27398819
http://dx.doi.org/10.1002/ana.24718
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