Cargando…

Toll-like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan

BACKGROUND: Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. Despite several studies reporting involvement of the innate immune receptor Toll-like receptor 2 (TLR2) in the recognition of surface glycolipids from Leishmania parasites in vitro, the role of TLR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Halliday, Alice, Bates, Paul A., Chance, Michael L., Taylor, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053327/ https://www.ncbi.nlm.nih.gov/pubmed/27716391 http://dx.doi.org/10.1186/s13071-016-1807-8

Ejemplares similares

Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis
por: Carneiro, Pedro Paulo, et al.
Publicado: (2021)

Leishmania infantum-derived lipophosphoglycan as an antigen in the accurate serodiagnosis of canine leishmaniasis
por: Portela, Ricardo Dias, et al.
Publicado: (2019)

Conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis
por: Topuzogullari, Murat, et al.
Publicado: (2013)

Intraspecies Polymorphisms in the Lipophosphoglycan of L. braziliensis Differentially Modulate Macrophage Activation via TLR4
por: Vieira, Tamara da Silva, et al.
Publicado: (2019)

Leishmania donovani and Cutaneous Leishmaniasis, Sri Lanka
por: Siriwardana, H. V. Yamuna D., et al.
Publicado: (2007)

Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan
por: Desjardins, Michel, et al.
Publicado: (1997)

Leishmania infantum Lipophosphoglycan-Deficient Mutants: A Tool to Study Host Cell-Parasite Interplay
por: Lázaro-Souza, Milena, et al.
Publicado: (2018)

Imaging of the host/parasite interplay in cutaneous leishmaniasis
por: Millington, Owain R., et al.
Publicado: (2010)

Leishmania infantum lipophosphoglycan induced-Prostaglandin E(2) production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2
por: Lima, Jonilson Berlink, et al.
Publicado: (2017)

Lipophosphoglycan From Dermotropic New World Leishmania Upregulates Interleukin-32 and Proinflammatory Cytokines Through TLR4 and NOD2 Receptors
por: Silveira, Murilo Barros, et al.
Publicado: (2022)

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence
por: Sansom, Fiona M., et al.
Publicado: (2014)

Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2 (−)) but Not Lipophosphoglycan (lpg1 (−)) for Survival in Permissive Sand Fly Vectors
por: Svárovská, Anna, et al.
Publicado: (2010)

Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2
por: Ihedioha, Olivia C., et al.
Publicado: (2023)

Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection
por: Nogueira, Paula M., et al.
Publicado: (2016)

Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
por: Dorlo, Thomas P. C., et al.
Publicado: (2011)

Ecology of cutaneous leishmaniasis in Sinai: linking parasites, vectors and hosts
por: Samy, Abdallah Mohammed, et al.
Publicado: (2014)

Cutaneous parasitism in patients with American visceral leishmaniasis in an endemic area
por: Moura, Carla Riama Lopes de Pádua, et al.
Publicado: (2020)

Leishmania (Mundinia) orientalis n. sp. (Trypanosomatidae), a parasite from Thailand responsible for localised cutaneous leishmaniasis
por: Jariyapan, Narissara, et al.
Publicado: (2018)

Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan
por: Franco, Luis H., et al.
Publicado: (2012)

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models
por: Halliday, Alice, et al.
Publicado: (2016)

Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling
por: Acevedo Ospina, Hamlet, et al.
Publicado: (2022)

Trypanosoma brucei Lipophosphoglycan Induces the Formation of Neutrophil Extracellular Traps and Reactive Oxygen Species Burst via Toll-Like Receptor 2, Toll-Like Receptor 4, and c-Jun N-Terminal Kinase Activation
por: Zhang, Kai, et al.
Publicado: (2021)

Drug-Resistant Leishmania tropica Parasites Detected in Iranian Cutaneous Leishmaniasis
Publicado: (2006)

Toll-Like Receptor 2 (TLR2) Plays a Major Role in Innate Resistance in the Lung against Murine Mycoplasma
por: Love, Wees, et al.
Publicado: (2010)

Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection
por: Al-Salem, Waleed S., et al.
Publicado: (2019)

Leishmania infantum Defective in Lipophosphoglycan Biosynthesis Interferes With Activation of Human Neutrophils
por: Quintela-Carvalho, Graziele, et al.
Publicado: (2022)

Survey of Wild Mammal Hosts of Cutaneous Leishmaniasis Parasites in Panamá and Costa Rica
por: González, Kadir, et al.
Publicado: (2015)

Cutaneous leishmaniasis in northwestern Saudi Arabia: identification of sand fly fauna and parasites
por: Haouas, Najoua, et al.
Publicado: (2017)

Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis
por: Christensen, Stephen M., et al.
Publicado: (2019)

Viral endosymbiotic infection of protozoan parasites: How it influences the development of cutaneous leishmaniasis
por: Lafleur, Andrea, et al.
Publicado: (2022)

Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis
Publicado: (1989)

CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists
por: Hernández-Ruiz, Joselín, et al.
Publicado: (2010)

Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromolar Affinity
por: Martins, Thaís Viana Fialho, et al.
Publicado: (2018)

Proteins involved in the biosynthesis of lipophosphoglycan in Leishmania: a comparative genomic and evolutionary analysis
por: Azevedo, Lucas Gentil, et al.
Publicado: (2020)

Cutaneous leishmaniasis mimicking cutaneous lymphoma
por: Pires, Carla Andréa Avelar, et al.
Publicado: (2019)

Exposure of Phosphatidylserine on Leishmania amazonensis Isolates Is Associated with Diffuse Cutaneous Leishmaniasis and Parasite Infectivity
por: França-Costa, Jaqueline, et al.
Publicado: (2012)

Cutaneous leishmaniasis in the central provinces of Hama and Edlib in Syria: Vector identification and parasite typing
por: Haddad, Nabil, et al.
Publicado: (2015)

Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis
por: Martínez-Valencia, Alvaro J., et al.
Publicado: (2017)

Unusual Presentation of Cutaneous Leishmaniasis: Ocular Leishmaniasis
por: Doroodgar, Masoud, et al.
Publicado: (2017)

Recurrent cutaneous leishmaniasis*
por: Gomes, Ciro Martins, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_s6qbf4aai48q1pkiuse7tv5o5k