Common variation at 10p12.31 near MLLT10 influences meningioma risk

To identify predisposition loci for meningioma we conducted a genome-wide association study of 859 cases and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a novel susceptibility locus for meningioma at 10p12.31 (MLLT10; rs11012732, O...

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Detalles Bibliográficos
Autores principales: Dobbins, Sara E, Broderick, Peter, Melin, Beatrice, Feychting, Maria, Johansen, Christoffer, Andersson, Ulrika, Brännström, Thomas, Schramm, Johannes, Olver, Bianca, Lloyd, Amy, Ma, Yussanne P, Hosking, Fay J, Lönn, Stefan, Ahlbom, Anders, Henriksson, Roger, Schoemaker, Minouk J, Hepworth, Sarah J, Hoffmann, Per, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Eisele, Lewin, Kosteljanetz, Michael, Muir, Kenneth, Swerdlow, Anthony, Simon, Matthias, Houlston, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053355/
https://www.ncbi.nlm.nih.gov/pubmed/21804547
http://dx.doi.org/10.1038/ng.879
Descripción
Sumario:To identify predisposition loci for meningioma we conducted a genome-wide association study of 859 cases and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a novel susceptibility locus for meningioma at 10p12.31 (MLLT10; rs11012732, OR=1.46, P(combined)=1.88x10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

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