Common variation at 10p12.31 near MLLT10 influences meningioma risk

To identify predisposition loci for meningioma we conducted a genome-wide association study of 859 cases and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a novel susceptibility locus for meningioma at 10p12.31 (MLLT10; rs11012732, O...

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Autores principales: Dobbins, Sara E, Broderick, Peter, Melin, Beatrice, Feychting, Maria, Johansen, Christoffer, Andersson, Ulrika, Brännström, Thomas, Schramm, Johannes, Olver, Bianca, Lloyd, Amy, Ma, Yussanne P, Hosking, Fay J, Lönn, Stefan, Ahlbom, Anders, Henriksson, Roger, Schoemaker, Minouk J, Hepworth, Sarah J, Hoffmann, Per, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Eisele, Lewin, Kosteljanetz, Michael, Muir, Kenneth, Swerdlow, Anthony, Simon, Matthias, Houlston, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053355/
https://www.ncbi.nlm.nih.gov/pubmed/21804547
http://dx.doi.org/10.1038/ng.879
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author Dobbins, Sara E
Broderick, Peter
Melin, Beatrice
Feychting, Maria
Johansen, Christoffer
Andersson, Ulrika
Brännström, Thomas
Schramm, Johannes
Olver, Bianca
Lloyd, Amy
Ma, Yussanne P
Hosking, Fay J
Lönn, Stefan
Ahlbom, Anders
Henriksson, Roger
Schoemaker, Minouk J
Hepworth, Sarah J
Hoffmann, Per
Mühleisen, Thomas W
Nöthen, Markus M
Moebus, Susanne
Eisele, Lewin
Kosteljanetz, Michael
Muir, Kenneth
Swerdlow, Anthony
Simon, Matthias
Houlston, Richard S
author_facet Dobbins, Sara E
Broderick, Peter
Melin, Beatrice
Feychting, Maria
Johansen, Christoffer
Andersson, Ulrika
Brännström, Thomas
Schramm, Johannes
Olver, Bianca
Lloyd, Amy
Ma, Yussanne P
Hosking, Fay J
Lönn, Stefan
Ahlbom, Anders
Henriksson, Roger
Schoemaker, Minouk J
Hepworth, Sarah J
Hoffmann, Per
Mühleisen, Thomas W
Nöthen, Markus M
Moebus, Susanne
Eisele, Lewin
Kosteljanetz, Michael
Muir, Kenneth
Swerdlow, Anthony
Simon, Matthias
Houlston, Richard S
author_sort Dobbins, Sara E
collection PubMed
description To identify predisposition loci for meningioma we conducted a genome-wide association study of 859 cases and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a novel susceptibility locus for meningioma at 10p12.31 (MLLT10; rs11012732, OR=1.46, P(combined)=1.88x10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
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spelling pubmed-50533552016-10-06 Common variation at 10p12.31 near MLLT10 influences meningioma risk Dobbins, Sara E Broderick, Peter Melin, Beatrice Feychting, Maria Johansen, Christoffer Andersson, Ulrika Brännström, Thomas Schramm, Johannes Olver, Bianca Lloyd, Amy Ma, Yussanne P Hosking, Fay J Lönn, Stefan Ahlbom, Anders Henriksson, Roger Schoemaker, Minouk J Hepworth, Sarah J Hoffmann, Per Mühleisen, Thomas W Nöthen, Markus M Moebus, Susanne Eisele, Lewin Kosteljanetz, Michael Muir, Kenneth Swerdlow, Anthony Simon, Matthias Houlston, Richard S Nat Genet Article To identify predisposition loci for meningioma we conducted a genome-wide association study of 859 cases and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a novel susceptibility locus for meningioma at 10p12.31 (MLLT10; rs11012732, OR=1.46, P(combined)=1.88x10(-14)). This finding advances our understanding of the genetic basis of meningioma development. 2011-07-31 /pmc/articles/PMC5053355/ /pubmed/21804547 http://dx.doi.org/10.1038/ng.879 Text en Users may view, print, copy, download and text and datamine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Dobbins, Sara E
Broderick, Peter
Melin, Beatrice
Feychting, Maria
Johansen, Christoffer
Andersson, Ulrika
Brännström, Thomas
Schramm, Johannes
Olver, Bianca
Lloyd, Amy
Ma, Yussanne P
Hosking, Fay J
Lönn, Stefan
Ahlbom, Anders
Henriksson, Roger
Schoemaker, Minouk J
Hepworth, Sarah J
Hoffmann, Per
Mühleisen, Thomas W
Nöthen, Markus M
Moebus, Susanne
Eisele, Lewin
Kosteljanetz, Michael
Muir, Kenneth
Swerdlow, Anthony
Simon, Matthias
Houlston, Richard S
Common variation at 10p12.31 near MLLT10 influences meningioma risk
title Common variation at 10p12.31 near MLLT10 influences meningioma risk
title_full Common variation at 10p12.31 near MLLT10 influences meningioma risk
title_fullStr Common variation at 10p12.31 near MLLT10 influences meningioma risk
title_full_unstemmed Common variation at 10p12.31 near MLLT10 influences meningioma risk
title_short Common variation at 10p12.31 near MLLT10 influences meningioma risk
title_sort common variation at 10p12.31 near mllt10 influences meningioma risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053355/
https://www.ncbi.nlm.nih.gov/pubmed/21804547
http://dx.doi.org/10.1038/ng.879
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