Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 cases and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P=8.70x10(-14)), 6p21.33 (rs2285803, PSORS1C2; P= 9.67x10(-11)), 17p11.2 (rs...

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Detalles Bibliográficos
Autores principales: Chubb, Daniel, Weinhold, Niels, Broderick, Peter, Chen, Bowang, Johnson, David C, Försti, Asta, Vijayakrishnan, Jayaram, Migliorini, Gabriele, Dobbins, Sara E, Holroyd, Amy, Hose, Dirk, Walker, Brian A, Davies, Faith E, Gregory, Walter A, Jackson, Graham H, Irving, Julie A, Pratt, Guy, Fegan, Chris, Fenton, James AL, Neben, Kai, Hoffmann, Per, Nöthen, Markus M, Mühleisen, Thomas W, Eisele, Lewin, Ross, Fiona M, Straka, Christian, Einsele, Hermann, Langer, Christian, Dörner, Elisabeth, Allan, James M, Jauch, Anna, Morgan, Gareth J, Hemminki, Kari, Houlston, Richard S, Goldschmidt, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053356/
https://www.ncbi.nlm.nih.gov/pubmed/23955597
http://dx.doi.org/10.1038/ng.2733
Descripción
Sumario:To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 cases and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P=8.70x10(-14)), 6p21.33 (rs2285803, PSORS1C2; P= 9.67x10(-11)), 17p11.2 (rs4273077, TNFRSF13B; P=7.67x10(-9)) and 22q13.1 (rs877529, CBX7; P=7.63x10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy and insight into the biological basis of predisposition.

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