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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 cases and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P=8.70x10(-14)), 6p21.33 (rs2285803, PSORS1C2; P= 9.67x10(-11)), 17p11.2 (rs...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053356/ https://www.ncbi.nlm.nih.gov/pubmed/23955597 http://dx.doi.org/10.1038/ng.2733 |
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| author | Chubb, Daniel Weinhold, Niels Broderick, Peter Chen, Bowang Johnson, David C Försti, Asta Vijayakrishnan, Jayaram Migliorini, Gabriele Dobbins, Sara E Holroyd, Amy Hose, Dirk Walker, Brian A Davies, Faith E Gregory, Walter A Jackson, Graham H Irving, Julie A Pratt, Guy Fegan, Chris Fenton, James AL Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Straka, Christian Einsele, Hermann Langer, Christian Dörner, Elisabeth Allan, James M Jauch, Anna Morgan, Gareth J Hemminki, Kari Houlston, Richard S Goldschmidt, Hartmut |
| author_facet | Chubb, Daniel Weinhold, Niels Broderick, Peter Chen, Bowang Johnson, David C Försti, Asta Vijayakrishnan, Jayaram Migliorini, Gabriele Dobbins, Sara E Holroyd, Amy Hose, Dirk Walker, Brian A Davies, Faith E Gregory, Walter A Jackson, Graham H Irving, Julie A Pratt, Guy Fegan, Chris Fenton, James AL Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Straka, Christian Einsele, Hermann Langer, Christian Dörner, Elisabeth Allan, James M Jauch, Anna Morgan, Gareth J Hemminki, Kari Houlston, Richard S Goldschmidt, Hartmut |
| author_sort | Chubb, Daniel |
| collection | PubMed |
| description | To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 cases and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P=8.70x10(-14)), 6p21.33 (rs2285803, PSORS1C2; P= 9.67x10(-11)), 17p11.2 (rs4273077, TNFRSF13B; P=7.67x10(-9)) and 22q13.1 (rs877529, CBX7; P=7.63x10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy and insight into the biological basis of predisposition. |
| format | Online Article Text |
| id | pubmed-5053356 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50533562016-10-06 Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk Chubb, Daniel Weinhold, Niels Broderick, Peter Chen, Bowang Johnson, David C Försti, Asta Vijayakrishnan, Jayaram Migliorini, Gabriele Dobbins, Sara E Holroyd, Amy Hose, Dirk Walker, Brian A Davies, Faith E Gregory, Walter A Jackson, Graham H Irving, Julie A Pratt, Guy Fegan, Chris Fenton, James AL Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Straka, Christian Einsele, Hermann Langer, Christian Dörner, Elisabeth Allan, James M Jauch, Anna Morgan, Gareth J Hemminki, Kari Houlston, Richard S Goldschmidt, Hartmut Nat Genet Article To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 cases and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P=8.70x10(-14)), 6p21.33 (rs2285803, PSORS1C2; P= 9.67x10(-11)), 17p11.2 (rs4273077, TNFRSF13B; P=7.67x10(-9)) and 22q13.1 (rs877529, CBX7; P=7.63x10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy and insight into the biological basis of predisposition. 2013-08-18 2013-10 /pmc/articles/PMC5053356/ /pubmed/23955597 http://dx.doi.org/10.1038/ng.2733 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Chubb, Daniel Weinhold, Niels Broderick, Peter Chen, Bowang Johnson, David C Försti, Asta Vijayakrishnan, Jayaram Migliorini, Gabriele Dobbins, Sara E Holroyd, Amy Hose, Dirk Walker, Brian A Davies, Faith E Gregory, Walter A Jackson, Graham H Irving, Julie A Pratt, Guy Fegan, Chris Fenton, James AL Neben, Kai Hoffmann, Per Nöthen, Markus M Mühleisen, Thomas W Eisele, Lewin Ross, Fiona M Straka, Christian Einsele, Hermann Langer, Christian Dörner, Elisabeth Allan, James M Jauch, Anna Morgan, Gareth J Hemminki, Kari Houlston, Richard S Goldschmidt, Hartmut Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| title | Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| title_full | Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| title_fullStr | Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| title_full_unstemmed | Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| title_short | Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| title_sort | common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053356/ https://www.ncbi.nlm.nih.gov/pubmed/23955597 http://dx.doi.org/10.1038/ng.2733 |
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