Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s Lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totaling 1,465 cases and 6,417 controls of European background),...

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Detalles Bibliográficos
Autores principales: Frampton, Matthew, da Silva Filho, Miguel Inacio, Broderick, Peter, Thomsen, Hauke, Försti, Asta, Vijayakrishnan, Jayaram, Cooke, Rosie, Enciso-Mora, Victor, Hoffmann, Per, Nöthen, Markus M, Lloyd, Amy, Holroyd, Amy, Eisele, Lewin, Jöckel, Karl-Heinz, Ponader, Sabine, von Strandmann, Elke Pogge, Lightfoot, Tracy, Roman, Eve, Lake, Annette, Montgomery, Dorothy, Jarrett, Ruth F, Swerdlow, Anthony J, Engert, Andreas, Hemminki, Kari, Houlston, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053363/
https://www.ncbi.nlm.nih.gov/pubmed/24149102
http://dx.doi.org/10.1038/ncomms3549
Descripción
Sumario:In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s Lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totaling 1,465 cases and 6,417 controls of European background), and follow up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14×10(-12), odds ratio [OR]=1.26) and 6q23.3 (rs7745098; P=3.42×10(-9), OR=1.21). rs3806624 localizes 5’ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with hematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

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