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Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma
In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s Lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totaling 1,465 cases and 6,417 controls of European background),...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053363/ https://www.ncbi.nlm.nih.gov/pubmed/24149102 http://dx.doi.org/10.1038/ncomms3549 |
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| author | Frampton, Matthew da Silva Filho, Miguel Inacio Broderick, Peter Thomsen, Hauke Försti, Asta Vijayakrishnan, Jayaram Cooke, Rosie Enciso-Mora, Victor Hoffmann, Per Nöthen, Markus M Lloyd, Amy Holroyd, Amy Eisele, Lewin Jöckel, Karl-Heinz Ponader, Sabine von Strandmann, Elke Pogge Lightfoot, Tracy Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F Swerdlow, Anthony J Engert, Andreas Hemminki, Kari Houlston, Richard S |
| author_facet | Frampton, Matthew da Silva Filho, Miguel Inacio Broderick, Peter Thomsen, Hauke Försti, Asta Vijayakrishnan, Jayaram Cooke, Rosie Enciso-Mora, Victor Hoffmann, Per Nöthen, Markus M Lloyd, Amy Holroyd, Amy Eisele, Lewin Jöckel, Karl-Heinz Ponader, Sabine von Strandmann, Elke Pogge Lightfoot, Tracy Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F Swerdlow, Anthony J Engert, Andreas Hemminki, Kari Houlston, Richard S |
| author_sort | Frampton, Matthew |
| collection | PubMed |
| description | In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s Lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totaling 1,465 cases and 6,417 controls of European background), and follow up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14×10(-12), odds ratio [OR]=1.26) and 6q23.3 (rs7745098; P=3.42×10(-9), OR=1.21). rs3806624 localizes 5’ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with hematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL. |
| format | Online Article Text |
| id | pubmed-5053363 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50533632016-10-06 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma Frampton, Matthew da Silva Filho, Miguel Inacio Broderick, Peter Thomsen, Hauke Försti, Asta Vijayakrishnan, Jayaram Cooke, Rosie Enciso-Mora, Victor Hoffmann, Per Nöthen, Markus M Lloyd, Amy Holroyd, Amy Eisele, Lewin Jöckel, Karl-Heinz Ponader, Sabine von Strandmann, Elke Pogge Lightfoot, Tracy Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F Swerdlow, Anthony J Engert, Andreas Hemminki, Kari Houlston, Richard S Nat Commun Article In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s Lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totaling 1,465 cases and 6,417 controls of European background), and follow up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14×10(-12), odds ratio [OR]=1.26) and 6q23.3 (rs7745098; P=3.42×10(-9), OR=1.21). rs3806624 localizes 5’ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with hematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL. 2013 /pmc/articles/PMC5053363/ /pubmed/24149102 http://dx.doi.org/10.1038/ncomms3549 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Frampton, Matthew da Silva Filho, Miguel Inacio Broderick, Peter Thomsen, Hauke Försti, Asta Vijayakrishnan, Jayaram Cooke, Rosie Enciso-Mora, Victor Hoffmann, Per Nöthen, Markus M Lloyd, Amy Holroyd, Amy Eisele, Lewin Jöckel, Karl-Heinz Ponader, Sabine von Strandmann, Elke Pogge Lightfoot, Tracy Roman, Eve Lake, Annette Montgomery, Dorothy Jarrett, Ruth F Swerdlow, Anthony J Engert, Andreas Hemminki, Kari Houlston, Richard S Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma |
| title | Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma |
| title_full | Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma |
| title_fullStr | Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma |
| title_full_unstemmed | Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma |
| title_short | Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s Lymphoma |
| title_sort | variation at 3p24.1 and 6q23.3 influences the risk of hodgkin’s lymphoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053363/ https://www.ncbi.nlm.nih.gov/pubmed/24149102 http://dx.doi.org/10.1038/ncomms3549 |
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