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Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia

PURPOSE: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia. DESIGN: This study is a prospective nonrandomized controlled study. SETTING: This study was conducted...

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Autor principal: Badawi, Amani E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053387/
https://www.ncbi.nlm.nih.gov/pubmed/27757009
http://dx.doi.org/10.2147/OPTH.S113412
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author Badawi, Amani E
author_facet Badawi, Amani E
author_sort Badawi, Amani E
collection PubMed
description PURPOSE: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia. DESIGN: This study is a prospective nonrandomized controlled study. SETTING: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt. METHODS: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm(2) for 9 minutes). Qualitative and quantitative analyses of the corneal endothelial cells were conducted before CXL and 3, 6, and 12 months after CXL by using a specular microscope (Tomy EM-3000). RESULTS: There was a significant reduction in endothelial cell count particularly at 3 and 6 months postCXL. In addition, the coefficient of variance was also statistically significantly higher at 3 and 6 months postoperatively than the preCXL value. There was a slight change in the percentage of hexagonal cells. CONCLUSION: The use of accelerated CXL (10 mW/cm(2) for 9 minutes) has a transient negative impact on endothelial cell density and/or endothelial morphology.
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spelling pubmed-50533872016-10-18 Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia Badawi, Amani E Clin Ophthalmol Original Research PURPOSE: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia. DESIGN: This study is a prospective nonrandomized controlled study. SETTING: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt. METHODS: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm(2) for 9 minutes). Qualitative and quantitative analyses of the corneal endothelial cells were conducted before CXL and 3, 6, and 12 months after CXL by using a specular microscope (Tomy EM-3000). RESULTS: There was a significant reduction in endothelial cell count particularly at 3 and 6 months postCXL. In addition, the coefficient of variance was also statistically significantly higher at 3 and 6 months postoperatively than the preCXL value. There was a slight change in the percentage of hexagonal cells. CONCLUSION: The use of accelerated CXL (10 mW/cm(2) for 9 minutes) has a transient negative impact on endothelial cell density and/or endothelial morphology. Dove Medical Press 2016-09-30 /pmc/articles/PMC5053387/ /pubmed/27757009 http://dx.doi.org/10.2147/OPTH.S113412 Text en © 2016 Badawi. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Badawi, Amani E
Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_full Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_fullStr Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_full_unstemmed Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_short Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_sort corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postlasik ectasia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053387/
https://www.ncbi.nlm.nih.gov/pubmed/27757009
http://dx.doi.org/10.2147/OPTH.S113412
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