Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats

Tetrahydrobiopterin (BH(4)) is an essential cofactor of nitric oxide synthase (NOS) and aromatic amino acid hydroxylases. BH(4) and 7,8-dihydrobiopterin (BH(2)) are metabolically interchangeable at the expense of NADPH. Exogenously administered BH(4) can be metabolized by the body, similar to vitami...

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Detalles Bibliográficos
Autores principales: Ohashi, Akiko, Saeki, Yusuke, Harada, Tomonori, Naito, Masako, Takahashi, Tomihisa, Aizawa, Shin, Hasegawa, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053593/
https://www.ncbi.nlm.nih.gov/pubmed/27711248
http://dx.doi.org/10.1371/journal.pone.0164305

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