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Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region

Non-small cell lung cancer (NSCLC) cells often possess a hypermethylated Keap1 promoter, which decreases Keap1 mRNA and protein expression levels, thus impairing the Nrf2-Keap1 pathway and thereby leading to chemo- or radio-resistance. In this study, we showed that genistein selectively exhibited a...

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Detalles Bibliográficos
Autores principales:	Liu, Xiongxiong, Sun, Chao, Liu, Bingtao, Jin, Xiaodong, Li, Ping, Zheng, Xiaogang, Zhao, Ting, Li, Feifei, Li, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053648/ https://www.ncbi.nlm.nih.gov/pubmed/27029077 http://dx.doi.org/10.18632/oncotarget.8403

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