Cargando…

Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells

Acute lymphoblastic leukaemia (ALL) is the most prevalent childhood malignancy. Although most children with ALL are cured, there is still a group of patients for which therapy fails owing to severe toxicities and drug resistance. Ginsenoside Rh2 (GRh2), a major bioactive component isolated from Pana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Ting, Wang, Jiancheng, Wang, Yingnan, Wang, Yuanyuan, Cai, Jianye, Wang, Min, Chen, Qidan, Song, Jia, Yu, Ziqi, Huang, Wei, Fang, Jianpei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053654/ https://www.ncbi.nlm.nih.gov/pubmed/27027340 http://dx.doi.org/10.18632/oncotarget.8285

Ejemplares similares

20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway
por: Xia, Ting, et al.
Publicado: (2020)

20(S)-Ginsenoside Rh2 Induce the Apoptosis and Autophagy in U937 and K562 Cells
por: Zhuang, Jianjian, et al.
Publicado: (2018)

Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation
por: Wang, Jiawen, et al.
Publicado: (2020)

Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
por: Salim, Landa Zeenelabdin Ali, et al.
Publicado: (2013)

Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2
por: Ren, Hong-can, et al.
Publicado: (2022)

The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity
por: Wang, Yu-Shi, et al.
Publicado: (2017)

A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy
por: Yang, Jing, et al.
Publicado: (2023)

Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
por: Wang, Hongbo, et al.
Publicado: (2012)

20(S)-ginsenoside Rh2 as agent for the treatment of LMN-CRC via regulating epithelial–mesenchymal transition
por: Yuan, Yihang, et al.
Publicado: (2020)

20(S)-Ginsenoside Rg3 Promotes HeLa Cell Apoptosis by Regulating Autophagy
por: Bian, Shuai, et al.
Publicado: (2019)

Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy
por: Yang, Zhiqing, et al.
Publicado: (2016)

The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
por: Lin, Yingjia, et al.
Publicado: (2017)

Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus
por: Kang, Soowon, et al.
Publicado: (2017)

(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2
por: Wang, Yu-Shi, et al.
Publicado: (2021)

Induction of apoptosis in prostate cancer by ginsenoside Rh2
por: Tong-Lin Wu, Tony, et al.
Publicado: (2018)

Identification of 20(S)-Ginsenoside Rh2 as a Potential EGFR Tyrosine Kinase Inhibitor
por: Liang, Yuan, et al.
Publicado: (2022)

Protective effect of ginsenoside Rh3 against anticancer drug-induced apoptosis in LLC-PK1 kidney cells
por: Lee, Hye Lim, et al.
Publicado: (2017)

Pharmacokinetic Comparison of 20(R)- and 20(S)-Ginsenoside Rh1 and 20(R)- and 20(S)-Ginsenoside Rg3 in Rat Plasma following Oral Administration of Radix Ginseng Rubra and Sheng-Mai-San Extracts
por: Fan, Xiaomei, et al.
Publicado: (2017)

(20S) Ginsenoside Rh2-Activated, Distinct Apoptosis Pathways in Highly and Poorly Differentiated Human Esophageal Cancer Cells
por: Li, He, et al.
Publicado: (2022)

Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells
por: Wang, Jiancheng, et al.
Publicado: (2018)

Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation
por: Wu, Yingchao, et al.
Publicado: (2022)

Transcriptome Analyses of the Anti-Proliferative Effects of 20(S)-Ginsenoside Rh2 on HepG2 Cells
por: Zhang, Ji, et al.
Publicado: (2019)

Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
por: Wang, Dan-Dan, et al.
Publicado: (2021)

Preparation of Polyethylene Glycol-Ginsenoside Rh1 and Rh2 Conjugates and Their Efficacy against Lung Cancer and Inflammation
por: Mathiyalagan, Ramya, et al.
Publicado: (2019)

Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency
por: Wang, Pingping, et al.
Publicado: (2019)

In vivo study of anticancer activity of ginsenoside Rh2-containing arginine-reduced graphene in a mouse model of breast cancer
por: Farhangfar, Shervin Dokht, et al.
Publicado: (2022)

Biotransformation of Ginsenoside Rf to Rh(1) by Recombinant β-Glucosidase
por: Ruan, Chang-Chun, et al.
Publicado: (2009)

20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo
por: Zhang, Haibo, et al.
Publicado: (2022)

T lymphoblastic leukaemia and the central nervous system.
por: Lilleyman, J. S., et al.
Publicado: (1981)

Long survival in childhood lymphoblastic leukaemia.
por: Chessells, J. M., et al.
Publicado: (1987)

Inotuzumab ozogamicin for acute lymphoblastic leukaemia
Publicado: (2019)

Targeted Therapy in Acute Lymphoblastic Leukaemia
por: Salvaris, Ross, et al.
Publicado: (2021)

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells: Ginsenoside Rh3 has anti-colorectal cancer properties
por: Wu, Yingchao, et al.
Publicado: (2023)

ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells
por: Cai, Jianye, et al.
Publicado: (2016)

Role of ginsenosides in reactive oxygen species-mediated anticancer therapy
por: Sodrul, Islam M.D., et al.
Publicado: (2017)

Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells
por: Li, Yunyao, et al.
Publicado: (2020)

The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation
por: Kang, Soouk, et al.
Publicado: (2014)

Ginsenoside Rh1 Improves the Effect of Dexamethasone on Autoantibodies Production and Lymphoproliferation in MRL/lpr Mice
por: Feng, Yinglu, et al.
Publicado: (2015)

Anticancer therapeutic effect of ginsenosides through mediating reactive oxygen species
por: Li, Xiaonan, et al.
Publicado: (2023)

Screening ginseng saponins in progenitor cells identifies 20(R)-ginsenoside Rh(2) as an enhancer of skeletal and cardiac muscle regeneration
por: Kim, Ah Ra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_me6gs88cbdj7nhk1d7iuekrila