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p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis

p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors, though the evidence is not yet conclusive. We therefore performed a meta-analysis to explore the relationship between PAK1 and prognosis in patients with solid tumors. Relevant...

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Autores principales: Fang, Fang, Pan, Jian, Li, Yi-Ping, Li, Gang, Xu, Li-Xiao, Su, Guang-Hao, Li, Zhi-Heng, Feng, Xing, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053660/
https://www.ncbi.nlm.nih.gov/pubmed/27027431
http://dx.doi.org/10.18632/oncotarget.8320
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author Fang, Fang
Pan, Jian
Li, Yi-Ping
Li, Gang
Xu, Li-Xiao
Su, Guang-Hao
Li, Zhi-Heng
Feng, Xing
Wang, Jian
author_facet Fang, Fang
Pan, Jian
Li, Yi-Ping
Li, Gang
Xu, Li-Xiao
Su, Guang-Hao
Li, Zhi-Heng
Feng, Xing
Wang, Jian
author_sort Fang, Fang
collection PubMed
description p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors, though the evidence is not yet conclusive. We therefore performed a meta-analysis to explore the relationship between PAK1 and prognosis in patients with solid tumors. Relevant publications were searched in several widely used databases, and 15 studies (3068 patients) were included in the meta-analysis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between PAK1 and prognosis. Associations between PAK1 expression and prognosis were observed for overall survival (HR = 2.81, 95% CI = 1.07-7.39) and disease-specific survival (HR = 2.15, 95% CI = 1.47-3.16). No such association was detected for time to tumor progression (HR = 1.78, 95% CI = 0.99-3.21).Our meta-analysis thus indicates that PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors.
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spelling pubmed-50536602016-10-12 p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis Fang, Fang Pan, Jian Li, Yi-Ping Li, Gang Xu, Li-Xiao Su, Guang-Hao Li, Zhi-Heng Feng, Xing Wang, Jian Oncotarget Research Paper p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) expression appears to be predictive of prognosis in various solid tumors, though the evidence is not yet conclusive. We therefore performed a meta-analysis to explore the relationship between PAK1 and prognosis in patients with solid tumors. Relevant publications were searched in several widely used databases, and 15 studies (3068 patients) were included in the meta-analysis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between PAK1 and prognosis. Associations between PAK1 expression and prognosis were observed for overall survival (HR = 2.81, 95% CI = 1.07-7.39) and disease-specific survival (HR = 2.15, 95% CI = 1.47-3.16). No such association was detected for time to tumor progression (HR = 1.78, 95% CI = 0.99-3.21).Our meta-analysis thus indicates that PAK1 expression may be a predictive marker of overall survival and disease-specific survival in patients with solid tumors. Impact Journals LLC 2016-03-24 /pmc/articles/PMC5053660/ /pubmed/27027431 http://dx.doi.org/10.18632/oncotarget.8320 Text en Copyright: © 2016 Fang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Fang, Fang
Pan, Jian
Li, Yi-Ping
Li, Gang
Xu, Li-Xiao
Su, Guang-Hao
Li, Zhi-Heng
Feng, Xing
Wang, Jian
p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis
title p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis
title_full p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis
title_fullStr p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis
title_full_unstemmed p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis
title_short p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis
title_sort p21-activated kinase 1 (pak1) expression correlates with prognosis in solid tumors: a systematic review and meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053660/
https://www.ncbi.nlm.nih.gov/pubmed/27027431
http://dx.doi.org/10.18632/oncotarget.8320
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