Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor

The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is aberrantly activated in multiple cancers and can promote proliferation and chemotherapy resistance. Multiple IGF-1R inhibitors have been developed as potential therapeutics. However, these inhibitors have failed to increase pati...

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Detalles Bibliográficos
Autores principales: Davaadelger, Batzaya, Duan, Lei, Perez, Ricardo E., Gitelis, Steven, Maki, Carl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053668/
https://www.ncbi.nlm.nih.gov/pubmed/27050276
http://dx.doi.org/10.18632/oncotarget.8484

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