Cargando…

PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction

Pancreatic cancer is characterized by a pronounced fibro-inflammatory reaction that has been shown to contribute to cancer progression. Previous reports have demonstrated that pigment epithelium-derived factor (PEDF) has potent tumor suppressive effects in pancreatic cancer, though little is known a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Principe, Daniel R., DeCant, Brian, Diaz, Andrew M., Mangan, Riley J., Hwang, Rosa, Lowy, Andrew, Shetuni, Brandon B., Sreekumar, Bharath K., Chung, Chuhan, Bentrem, David J., Munshi, Hidayatullah G., Jung, Barbara, Grippo, Paul J., Bishehsari, Faraz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053722/ https://www.ncbi.nlm.nih.gov/pubmed/27058416 http://dx.doi.org/10.18632/oncotarget.8587

Ejemplares similares

TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function
por: Principe, D R, et al.
Publicado: (2017)

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells
por: Ebine, Kazumi, et al.
Publicado: (2018)

Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation
por: Principe, Daniel R., et al.
Publicado: (2016)

Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia
por: Ebine, Kazumi, et al.
Publicado: (2016)

Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver
por: Protiva, Petr, et al.
Publicado: (2015)

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models
por: DeCant, Brian T., et al.
Publicado: (2014)

Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer
por: Schultz, Michelle A., et al.
Publicado: (2017)

Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease
por: Sagheer, Usman, et al.
Publicado: (2015)

Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
por: Krantz, Seth B., et al.
Publicado: (2010)

Pressure-Induced Alterations in PEDF and PEDF-R Expression: Implications for Neuroprotective Signaling in Glaucoma
por: Lee, Sean J, et al.
Publicado: (2015)

Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI
por: Belinsky, Glenn S., et al.
Publicado: (2016)

Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis
por: Michalczyk, Elizabeth R., et al.
Publicado: (2018)

Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies
por: Pham, Thao N. D., et al.
Publicado: (2021)

Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8(+) T cell antitumor immunity
por: Pham, Thao N.D., et al.
Publicado: (2022)

Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota
por: Bishehsari, Faraz, et al.
Publicado: (2016)

Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer
por: Kumar, Krishan, et al.
Publicado: (2023)

PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL
por: Zhang, Hao, et al.
Publicado: (2015)

Pigment Epithelium‐Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF‐R)
por: Lu, Peng, et al.
Publicado: (2016)

Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway
por: Ding, Yongzeng, et al.
Publicado: (2018)

The difficulty in translating the preclinical success of combined TGFβ and immune checkpoint inhibition to clinical trial
por: Metropulos, Anastasia E., et al.
Publicado: (2022)

The Role of PEDF in Reproductive Aging of the Ovary †
por: Nemerovsky, Luba, et al.
Publicado: (2022)

PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2
por: Zhou, Zhongxin, et al.
Publicado: (2016)

PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition
por: Li, Yufeng, et al.
Publicado: (2018)

Fibro-Sarcoma of the Orbit
por: Ray, J. Morrison
Publicado: (1899)

Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1
por: Pham, Thao N.D., et al.
Publicado: (2019)

Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer
por: Principe, Daniel R., et al.
Publicado: (2021)

Response to Rathi et al.
por: Bishehsari, Faraz
Publicado: (2020)

The Emerging Role of PEDF in Stem Cell Biology
por: Elahy, Mina, et al.
Publicado: (2012)

PEDF – A Noninhibitory Serpin with Neurotrophic Activity
por: Minkevich, N.I., et al.
Publicado: (2010)

Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis
por: Bishehsari, Faraz, et al.
Publicado: (2019)

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF-R
por: Zhao, Qixiang, et al.
Publicado: (2018)

Pigment Epithelium-Derived Factor (PEDF) Protects Osteoblastic Cell Line from Glucocorticoid-Induced Apoptosis via PEDF-R
por: Yao, Shengcheng, et al.
Publicado: (2016)

Alveolar soft part sarcoma mimics prostate cancer metastasis
por: Principe, Daniel R, et al.
Publicado: (2019)

A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis
por: Li, Xinghui, et al.
Publicado: (2023)

Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation
por: Gounaris, Elias, et al.
Publicado: (2015)

PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect
por: Gao, Xiao, et al.
Publicado: (2014)

Codon Preference Optimization Increases Heterologous PEDF Expression
por: Gvritishvili, Anzor G., et al.
Publicado: (2010)

The contrary intracellular and extracellular functions of PEDF in HCC development
por: Li, Cen, et al.
Publicado: (2019)

PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE
por: Rebustini, Ivan T., et al.
Publicado: (2022)

Receptors that bind to PEDF and their therapeutic roles in retinal diseases
por: Xu, Manhong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n11i4lhvqegghab3rtriiqpr02