Cargando…

ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion

Tumor invasion can be induced by changes in gene expression that alter cell phenotype. The transcription factor ΔNp63α promotes basal-like breast cancer (BLBC) migration by inducing the expression of the mesenchymal genes Slug and Axl, which confers cells with a hybrid epithelial/mesenchymal state....

Descripción completa

Detalles Bibliográficos
Autores principales:	Dang, Tuyen T., Westcott, Jill M., Maine, Erin A., Kanchwala, Mohammed, Xing, Chao, Pearson, Gray W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053748/ https://www.ncbi.nlm.nih.gov/pubmed/27081041 http://dx.doi.org/10.18632/oncotarget.8696

Ejemplares similares

The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion
por: Maine, Erin A., et al.
Publicado: (2016)

ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation
por: Kim, Kyu-Han, et al.
Publicado: (2015)

ΔNp63α-mediated epigenetic regulation in keratinocyte senescence
por: Kuang, Linghan, et al.
Publicado: (2023)

ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion
por: Wu, J, et al.
Publicado: (2014)

c-Abl phosphorylation of ΔNp63α is critical for cell viability
por: Yuan, M, et al.
Publicado: (2010)

ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition
por: Stacy, Andrew J., et al.
Publicado: (2016)

ΔNp63 drives epithelial differentiation in glioma
por: Lu, Jia‐Hao, et al.
Publicado: (2020)

Dual regulation of TERT activity through transcription and splicing by ΔNP63α
por: Vorovich, Esther, et al.
Publicado: (2008)

ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response: ΔNp63α may cause genomic instability in epithelial stem cells
por: Kudo, Ken-ichi, et al.
Publicado: (2022)

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy
por: Salah, Z, et al.
Publicado: (2013)

ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion
por: Yang, Kuan, et al.
Publicado: (2016)

DNA damage induces expression of WWP1 to target ΔNp63α to degradation
por: Chen, Ji, et al.
Publicado: (2017)

E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma
por: Xu, Jing, et al.
Publicado: (2021)

ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells
por: Van Sciver, Nicholas, et al.
Publicado: (2021)

ΔNp63 Is Essential for Epidermal Commitment of Embryonic Stem Cells
por: Medawar, Alain, et al.
Publicado: (2008)

ΔNp63 mediates cellular survival and metastasis in canine osteosarcoma
por: Cam, Maren, et al.
Publicado: (2016)

ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells
por: Gallant-Behm, Corrie L., et al.
Publicado: (2013)

ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2
por: Ram Kumar, Ram Mohan, et al.
Publicado: (2014)

ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis
por: Bergholz, Johann, et al.
Publicado: (2012)

Targeting of ΔNp63α by miR‐522 promotes the migration of breast epithelial cells
por: Dong, Yuanyuan, et al.
Publicado: (2021)

Correction: E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma
por: Xu, Jing, et al.
Publicado: (2022)

ΔNp63α facilitates proliferation and migration, and modulates the chromatin landscape in intrahepatic cholangiocarcinoma cells
por: Peng, Anghui, et al.
Publicado: (2023)

A Hidden Role of the Inactivated FANCD2: Upregulating ΔNp63
por: Panneerselvam, Jayabal, et al.
Publicado: (2013)

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma
por: Kumakura, Yuji, et al.
Publicado: (2017)

ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells
por: Nekulova, Marta, et al.
Publicado: (2016)

Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
por: Citro, Simona, et al.
Publicado: (2020)

SYT7 acts as an oncogene and a potential therapeutic target and was regulated by ΔNp63α in HNSCC
por: Fu, You, et al.
Publicado: (2021)

Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation
por: Wang, Liang-Jie, et al.
Publicado: (2022)

ΔNp63α suppresses cells invasion by downregulating PKCγ/Rac1 signaling through miR-320a
por: Aljagthmi, Amjad A., et al.
Publicado: (2019)

ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis
por: Park, Sunyoung, et al.
Publicado: (2019)

DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma
por: Pokorna, Zuzana, et al.
Publicado: (2022)

ΔNp63α modulates histone methyl transferase SETDB1 to transcriptionally repress target genes in cancers
por: Regina, C, et al.
Publicado: (2016)

ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82
por: Di Giacomo, V, et al.
Publicado: (2017)

SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of ΔNp63α protein
por: Ying, Liu, et al.
Publicado: (2020)

ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis
por: Rizzo, J M, et al.
Publicado: (2016)

Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis
por: Regina, Carla, et al.
Publicado: (2016)

Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma
por: Yoshida, Masakazu, et al.
Publicado: (2018)

Tmub1 Suppresses Hepatocellular Carcinoma by Promoting the Ubiquitination of ΔNp63 Isoforms
por: Fu, Hangwei, et al.
Publicado: (2020)

ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells
por: Sato, Kota, et al.
Publicado: (2023)

1α, 25-Dihydroxyvitamin D(3) and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferation
por: Hill, N T, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_s26tq36s8dvjhpek9efjjj1vo4