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Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma

Clinical and histopathological characteristics of 16 dogs with nodal paracortical (T-zone) lymphoma (TZL) were evaluated. At initial examination, generalized lymphadenopathy was found in all dogs, and peripheral lymphocytosis was found in 10 of the 16 dogs. At initial diagnosis or during the disease...

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Autores principales: MIZUTANI, Noriyuki, GOTO-KOSHINO, Yuko, TAKAHASHI, Masashi, UCHIDA, Kazuyuki, TSUJIMOTO, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053923/
https://www.ncbi.nlm.nih.gov/pubmed/27098109
http://dx.doi.org/10.1292/jvms.15-0688
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author MIZUTANI, Noriyuki
GOTO-KOSHINO, Yuko
TAKAHASHI, Masashi
UCHIDA, Kazuyuki
TSUJIMOTO, Hajime
author_facet MIZUTANI, Noriyuki
GOTO-KOSHINO, Yuko
TAKAHASHI, Masashi
UCHIDA, Kazuyuki
TSUJIMOTO, Hajime
author_sort MIZUTANI, Noriyuki
collection PubMed
description Clinical and histopathological characteristics of 16 dogs with nodal paracortical (T-zone) lymphoma (TZL) were evaluated. At initial examination, generalized lymphadenopathy was found in all dogs, and peripheral lymphocytosis was found in 10 of the 16 dogs. At initial diagnosis or during the disease course, 8 dogs (50%) were affected with demodicosis. Immunohistochemical analysis for CD3, CD20 and CD25 was performed for 6 dogs with TZL; the tumor cells were positive for CD3 and CD25 and negative for CD20. Median overall survival time was 938 days. A watchful waiting approach was adopted for 6 cases (38%), and 5 of the 6 dogs were still alive at the end of follow-up. The clinical course of TZL in dogs is generally indolent; however, many cases develop a variety of infectious and other neoplastic diseases after the diagnosis of TZL.
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spelling pubmed-50539232016-10-07 Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma MIZUTANI, Noriyuki GOTO-KOSHINO, Yuko TAKAHASHI, Masashi UCHIDA, Kazuyuki TSUJIMOTO, Hajime J Vet Med Sci Internal Medicine Clinical and histopathological characteristics of 16 dogs with nodal paracortical (T-zone) lymphoma (TZL) were evaluated. At initial examination, generalized lymphadenopathy was found in all dogs, and peripheral lymphocytosis was found in 10 of the 16 dogs. At initial diagnosis or during the disease course, 8 dogs (50%) were affected with demodicosis. Immunohistochemical analysis for CD3, CD20 and CD25 was performed for 6 dogs with TZL; the tumor cells were positive for CD3 and CD25 and negative for CD20. Median overall survival time was 938 days. A watchful waiting approach was adopted for 6 cases (38%), and 5 of the 6 dogs were still alive at the end of follow-up. The clinical course of TZL in dogs is generally indolent; however, many cases develop a variety of infectious and other neoplastic diseases after the diagnosis of TZL. The Japanese Society of Veterinary Science 2016-04-21 2016-08 /pmc/articles/PMC5053923/ /pubmed/27098109 http://dx.doi.org/10.1292/jvms.15-0688 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Internal Medicine
MIZUTANI, Noriyuki
GOTO-KOSHINO, Yuko
TAKAHASHI, Masashi
UCHIDA, Kazuyuki
TSUJIMOTO, Hajime
Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma
title Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma
title_full Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma
title_fullStr Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma
title_full_unstemmed Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma
title_short Clinical and histopathological evaluation of 16 dogs with T-zone lymphoma
title_sort clinical and histopathological evaluation of 16 dogs with t-zone lymphoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053923/
https://www.ncbi.nlm.nih.gov/pubmed/27098109
http://dx.doi.org/10.1292/jvms.15-0688
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