Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 µg) was associat...

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Autores principales: KANAI, Kazutaka, NAGATA, Sho, HATTA, Takuya, SUGIURA, Yuichi, SATO, Kazuaki, YAMASHITA, Yohei, KIMURA, Yuya, ITOH, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2016
Materias:
Clinical Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053947/
https://www.ncbi.nlm.nih.gov/pubmed/27170432
http://dx.doi.org/10.1292/jvms.16-0196
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author KANAI, Kazutaka
NAGATA, Sho
HATTA, Takuya
SUGIURA, Yuichi
SATO, Kazuaki
YAMASHITA, Yohei
KIMURA, Yuya
ITOH, Naoyuki
author_facet KANAI, Kazutaka
NAGATA, Sho
HATTA, Takuya
SUGIURA, Yuichi
SATO, Kazuaki
YAMASHITA, Yohei
KIMURA, Yuya
ITOH, Naoyuki
author_sort KANAI, Kazutaka
collection PubMed
description The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 µg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.
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spelling pubmed-50539472016-10-07 Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats KANAI, Kazutaka NAGATA, Sho HATTA, Takuya SUGIURA, Yuichi SATO, Kazuaki YAMASHITA, Yohei KIMURA, Yuya ITOH, Naoyuki J Vet Med Sci Clinical Pathology The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 µg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis. The Japanese Society of Veterinary Science 2016-05-07 2016-08 /pmc/articles/PMC5053947/ /pubmed/27170432 http://dx.doi.org/10.1292/jvms.16-0196 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Clinical Pathology
KANAI, Kazutaka
NAGATA, Sho
HATTA, Takuya
SUGIURA, Yuichi
SATO, Kazuaki
YAMASHITA, Yohei
KIMURA, Yuya
ITOH, Naoyuki
Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
title Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
title_full Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
title_fullStr Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
title_full_unstemmed Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
title_short Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats
title_sort therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in lewis rats
topic Clinical Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053947/
https://www.ncbi.nlm.nih.gov/pubmed/27170432
http://dx.doi.org/10.1292/jvms.16-0196
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