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A Brief Review of Short Tandem Repeat Mutation
Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the step...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054066/ https://www.ncbi.nlm.nih.gov/pubmed/17572359 http://dx.doi.org/10.1016/S1672-0229(07)60009-6 |
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author | Fan, Hao Chu, Jia-You |
author_facet | Fan, Hao Chu, Jia-You |
author_sort | Fan, Hao |
collection | PubMed |
description | Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation. |
format | Online Article Text |
id | pubmed-5054066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50540662016-10-14 A Brief Review of Short Tandem Repeat Mutation Fan, Hao Chu, Jia-You Genomics Proteomics Bioinformatics Review Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation. Elsevier 2007 2007-06-15 /pmc/articles/PMC5054066/ /pubmed/17572359 http://dx.doi.org/10.1016/S1672-0229(07)60009-6 Text en © 2007 Beijing Institute of Genomics http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Review Fan, Hao Chu, Jia-You A Brief Review of Short Tandem Repeat Mutation |
title | A Brief Review of Short Tandem Repeat Mutation |
title_full | A Brief Review of Short Tandem Repeat Mutation |
title_fullStr | A Brief Review of Short Tandem Repeat Mutation |
title_full_unstemmed | A Brief Review of Short Tandem Repeat Mutation |
title_short | A Brief Review of Short Tandem Repeat Mutation |
title_sort | brief review of short tandem repeat mutation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054066/ https://www.ncbi.nlm.nih.gov/pubmed/17572359 http://dx.doi.org/10.1016/S1672-0229(07)60009-6 |
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