Cargando…

Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data

Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Wei-Po, Yang, Kung-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054112/
https://www.ncbi.nlm.nih.gov/pubmed/18973867
http://dx.doi.org/10.1016/S1672-0229(08)60026-1
_version_ 1782458529067565056
author Lee, Wei-Po
Yang, Kung-Cheng
author_facet Lee, Wei-Po
Yang, Kung-Cheng
author_sort Lee, Wei-Po
collection PubMed
description Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully.
format Online
Article
Text
id pubmed-5054112
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-50541122016-10-14 Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data Lee, Wei-Po Yang, Kung-Cheng Genomics Proteomics Bioinformatics Method Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully. Elsevier 2008 2008-10-28 /pmc/articles/PMC5054112/ /pubmed/18973867 http://dx.doi.org/10.1016/S1672-0229(08)60026-1 Text en © 2008 Beijing Institute of Genomics http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Method
Lee, Wei-Po
Yang, Kung-Cheng
Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
title Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
title_full Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
title_fullStr Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
title_full_unstemmed Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
title_short Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
title_sort applying intelligent computing techniques to modeling biological networks from expression data
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054112/
https://www.ncbi.nlm.nih.gov/pubmed/18973867
http://dx.doi.org/10.1016/S1672-0229(08)60026-1
work_keys_str_mv AT leeweipo applyingintelligentcomputingtechniquestomodelingbiologicalnetworksfromexpressiondata
AT yangkungcheng applyingintelligentcomputingtechniquestomodelingbiologicalnetworksfromexpressiondata