Human Split-Thickness Skin Allograft from Brain-Dead Donors

BACKGROUND: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. OBJECTIVE: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbi...

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Detalles Bibliográficos
Autores principales: Khodadadi, A., Olang, O, Makhllough, A, Nozary Heshmati, B., Azmoudeh Ardalan, F., Tavakoli, S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Organ Transplantation Institute 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054143/
https://www.ncbi.nlm.nih.gov/pubmed/27721966
Descripción
Sumario:BACKGROUND: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. OBJECTIVE: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits. METHODS: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors. RESULTS: On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15–20 days. CONCLUSION: Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns.

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