Human Split-Thickness Skin Allograft from Brain-Dead Donors

BACKGROUND: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. OBJECTIVE: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbi...

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Autores principales: Khodadadi, A., Olang, O, Makhllough, A, Nozary Heshmati, B., Azmoudeh Ardalan, F., Tavakoli, S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Organ Transplantation Institute 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054143/
https://www.ncbi.nlm.nih.gov/pubmed/27721966
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author Khodadadi, A.
Olang, O
Makhllough, A
Nozary Heshmati, B.
Azmoudeh Ardalan, F.
Tavakoli, S. A.
author_facet Khodadadi, A.
Olang, O
Makhllough, A
Nozary Heshmati, B.
Azmoudeh Ardalan, F.
Tavakoli, S. A.
author_sort Khodadadi, A.
collection PubMed
description BACKGROUND: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. OBJECTIVE: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits. METHODS: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors. RESULTS: On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15–20 days. CONCLUSION: Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns.
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spelling pubmed-50541432016-10-07 Human Split-Thickness Skin Allograft from Brain-Dead Donors Khodadadi, A. Olang, O Makhllough, A Nozary Heshmati, B. Azmoudeh Ardalan, F. Tavakoli, S. A. Int J Organ Transplant Med Original Article BACKGROUND: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. OBJECTIVE: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits. METHODS: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors. RESULTS: On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15–20 days. CONCLUSION: Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns. Avicenna Organ Transplantation Institute 2016 2016-08-01 /pmc/articles/PMC5054143/ /pubmed/27721966 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khodadadi, A.
Olang, O
Makhllough, A
Nozary Heshmati, B.
Azmoudeh Ardalan, F.
Tavakoli, S. A.
Human Split-Thickness Skin Allograft from Brain-Dead Donors
title Human Split-Thickness Skin Allograft from Brain-Dead Donors
title_full Human Split-Thickness Skin Allograft from Brain-Dead Donors
title_fullStr Human Split-Thickness Skin Allograft from Brain-Dead Donors
title_full_unstemmed Human Split-Thickness Skin Allograft from Brain-Dead Donors
title_short Human Split-Thickness Skin Allograft from Brain-Dead Donors
title_sort human split-thickness skin allograft from brain-dead donors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054143/
https://www.ncbi.nlm.nih.gov/pubmed/27721966
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