Biogenesis of Mammalian MicroRNAs: A Global View

MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article...

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Detalles Bibliográficos
Autores principales: Graves, Paul, Zeng, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054211/
https://www.ncbi.nlm.nih.gov/pubmed/23200133
http://dx.doi.org/10.1016/j.gpb.2012.06.004
Descripción
Sumario:MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article reviews our current knowledge of the mechanism and regulation of mammalian miRNA expression and points out areas of research that may enhance our understanding of how the specificity and efficiency of miRNA production is controlled in vivo.

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