Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation and plasticity, via control of actin cytoskeleton dynamic. Their activity is positively and negatively regulated by GEFs and GAPs molecules, respectively. However their in v...

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Detalles Bibliográficos
Autores principales: Zamboni, Valentina, Armentano, Maria, Sarò, Gabriella, Ciraolo, Elisa, Ghigo, Alessandra, Germena, Giulia, Umbach, Alessandro, Valnegri, Pamela, Passafaro, Maria, Carabelli, Valentina, Gavello, Daniela, Bianchi, Veronica, D’Adamo, Patrizia, de Curtis, Ivan, El-Assawi, Nadia, Mauro, Alessandro, Priano, Lorenzo, Ferri, Nicola, Hirsch, Emilio, Merlo, Giorgio R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054378/
https://www.ncbi.nlm.nih.gov/pubmed/27713499
http://dx.doi.org/10.1038/srep34877

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