Use of aerosol route to fabricate positively charged Au/Fe(3)O(4) Janus nanoparticles as multifunctional nanoplatforms

Gold (Au)-decorated iron oxide (Fe(3)O(4)), Au/Fe(3)O(4), Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe(3)O(4) domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-...

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Detalles Bibliográficos
Autores principales: Byeon, Jeong Hoon, Park, Jae Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054399/
https://www.ncbi.nlm.nih.gov/pubmed/27713519
http://dx.doi.org/10.1038/srep35104
Descripción
Sumario:Gold (Au)-decorated iron oxide (Fe(3)O(4)), Au/Fe(3)O(4), Janus nanoparticles were fabricated via the continuous route for aerosol Au incorporation with Fe(3)O(4) domains synthesized in an aqueous medium as multifunctional nanoplatforms. The fabricated nanoparticles were subsequently exposed to 185-nm UV light to generate positive charges on Au surfaces, and their activities were tested in computed tomography (CT) and magnetic resonance (MR) imaging, gene-delivery and photothermal therapy. No additional polymeric coatings of the Janus particles also had a unique ability to suppress inflammatory responses in macrophages challenged with lipopolysaccharide, which may be due to the absence of amine groups.

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