The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease

Huntington disease (HD) is an autosomal neurodegenerative disorder caused by the expansion of Polyglutamine (polyQ) in exon 1 of the Huntingtin protein. Glutamine repeats below 36 are considered normal while repeats above 40 lead to HD. Impairment in energy metabolism is a common trend in Huntington...

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Detalles Bibliográficos
Autores principales: Sameni, Sara, Syed, Adeela, Marsh, J. Lawrence, Digman, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054433/
https://www.ncbi.nlm.nih.gov/pubmed/27713486
http://dx.doi.org/10.1038/srep34755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054433/
https://www.ncbi.nlm.nih.gov/pubmed/27713486
http://dx.doi.org/10.1038/srep34755

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