Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice

Genetic deletion of the tyrosine kinase JAK2 or the downstream transcription factor STAT5 in liver impairs growth hormone (GH) signalling and thereby promotes fatty liver disease. Hepatic STAT5 deficiency accelerates liver tumourigenesis in presence of high GH levels. To determine whether the upstre...

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Detalles Bibliográficos
Autores principales: Themanns, Madeleine, Mueller, Kristina M., Kessler, Sonja M., Golob-Schwarzl, Nicole, Mohr, Thomas, Kaltenecker, Doris, Bourgeais, Jerome, Paier-Pourani, Jamile, Friedbichler, Katrin, Schneller, Doris, Schlederer, Michaela, Zebedin-Brandl, Eva, Terracciano, Luigi M., Han, Xiaonan, Kenner, Lukas, Wagner, Kay-Uwe, Mikulits, Wolfgang, Kozlov, Andrey V., Heim, Markus H., Gouilleux, Fabrice, Haybaeck, Johannes, Moriggl, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054456/
https://www.ncbi.nlm.nih.gov/pubmed/27713471
http://dx.doi.org/10.1038/srep34719

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