AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells

The AML1/ETO fusion protein found in acute myeloid leukemias functions as a transcriptional regulator by recruiting co-repressor complexes to its DNA binding site. In order to extend the understanding of its role in preleukemia, we expressed AML1/ETO in a murine immortalized pluripotent hematopoieti...

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Detalles Bibliográficos
Autores principales: Saia, Marco, Termanini, Alberto, Rizzi, Nicoletta, Mazza, Massimiliano, Barbieri, Elisa, Valli, Debora, Ciana, Paolo, Gruszka, Alicja M., Alcalay, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054523/
https://www.ncbi.nlm.nih.gov/pubmed/27713544
http://dx.doi.org/10.1038/srep34957

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